Changes in Gene Expression and Protein Insolubility in Alzheimer’s Disease Progression Background Introduction As the most common type of dementia, Alzheimer’s Disease (AD) is well-known for its two main neuropathological features: amyloid plaques and neurofibrillary tangles (NFTs). Amyloid plaques consist of β-amyloid (Aβ) peptide segments generat...
Detection of Seeding Activity of Human Superoxide Dismutase 1 Aggregates in Postmortem Neural Tissues of Familial and Sporadic Amyotrophic Lateral Sclerosis Patients Background Introduction Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disease with an average survival time of 2 to 5 years after diagnosis. Major symp...
Stage-Dependent Immune Responses Mediated by AQP4 Antibodies in NMOSD Pathology in the Central Nervous System Academic Background Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune diseases of the central nervous system (CNS), characterized by the production of specific antibodies against the water channel protein Aquaporin-4 (AQP4). Al...
Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...
The Influence of APOEε4 on the pTau Interactome in Sporadic Alzheimer’s Disease Background Alzheimer’s disease (AD) is a neurodegenerative disease characterized by extracellular deposition and aggregation of β-amyloid protein (Aβ) forming various types of Aβ deposits and the intracellular accumulation and assembly of abnormally phosphorylated tau p...
Neuroinformatics Research: 3D Modeling of Neuroanatomy with Multi-Camera System Academic Background The surgical anatomy of the central nervous system, including the skull and spine, has an extremely complex three-dimensional (3D) structure, making it difficult for learners to fully understand the intricate relationships between various structures....
Characteristics of Premature Cellular Senescence in Alzheimer’s Disease: Application of Single-Nucleus Transcriptomics Research Background and Objectives Alzheimer’s disease (AD) is the most common type of dementia in the elderly, characterized by extracellular deposition of β-amyloid protein and intracellular neurofibrillary tangles. Other patholo...
Cerebral amyloid angiopathy (CAA) is a disease caused by the deposition of amyloid-beta (Aβ) in cerebral blood vessels. It is common not only in the elderly and almost all patients with Alzheimer’s disease (AD) but can also occur independently of other AD-related pathologies. The presence and severity of CAA promote the progression of AD-related cl...
Study on the Efficacy of Erdafitinib in Patients with Tumors with FGFR Mutations or Fusions This academic report is based on the scientific paper “Phase II Study of Erdafitinib in Patients with Tumors with Fibroblast Growth Factor Receptor Mutations or Fusions: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K2,” and introduces the...
Research Background In recent years, Poly ADP-ribose Polymerase (PARP) inhibitors have shown significant efficacy as a key approach to treat hereditary BRCA1/2 mutation cancers. However, their effectiveness on tumors with other homologous recombination deficiency (HRD) gene mutations such as ATM, CDK12, and CHEK2 has been less satisfactory. Hence, ...