Imaging Study of Brain Glucose Metabolism in Patients with Pyruvate Dehydrogenase Deficiency Background In modern mitochondrial medicine, evaluating the spectrum of brain diseases has been a limiting challenge. This limitation hinders our ability to understand the mechanisms behind the imaging phenotypes of the brains of mitochondrial disease patie...
Nonverbal Oral Apraxia in Patients with Neurodegenerative Diseases: Clinical-Pathological and Neuroimaging Correlations Research Background Nonverbal Oral Apraxia (NVOA) is a condition characterized by the inability to plan, sequence, and execute voluntary oral-facial movements without muscle weakness. NVOA was first identified in stroke patients, ...
Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...
Research Report on the Effects of Naringin Intervention on Newborn Neurons and BDNF Levels in Rat Brain Ischemia-Reperfusion Model Background With the global increase in cardiovascular diseases, ischemic stroke has gradually become a major cause of death and disability, affecting the quality of life of millions of people. Despite continuous advance...
A Study Exploring a New Mutation in Early-Onset Alzheimer’s Disease Alzheimer’s Disease (AD) is a common neurodegenerative disorder, accounting for 60-70% of all dementia cases. In recent years, with global population aging and environmental changes, the incidence of AD has been increasing annually. It is predicted that by 2050, the number of patie...
Mechanism Study of Circular RNA-GRIN2B Inhibiting Neuropathic Pain Background Introduction Neuropathic pain is a persistent pain caused by damage to the somatic sensory nervous system, with its etiology not yet fully understood and clinical treatment facing many difficulties. Given the complexity of neuropathic pain, there is an urgent need to reve...
Scientific Research Report: Drug Treatment Alleviates Retinal Ganglion Cell Death in Normal Tension Glaucoma Mouse Model by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation Background Normal Tension Glaucoma (NTG) is a progressive neurodegenerative disease in the glaucoma family. Typically, glaucoma is associated with elevated intra...
The Role of p39 in Cerebral Ischemic Injury Background Introduction Stroke is an extremely serious public health problem, with current research mainly focusing on injury mechanisms and new target identification. p39, as an activator of CDK5 (Cyclin-dependent kinase 5), plays a crucial role in various diseases. This article mainly investigates the r...
Pediatric medulloblastoma (MB) is the most common malignant pediatric brain tumor. Due to its unique molecular and clinical characteristics, the treatment of this type of tumor has been a focus of clinical research. Existing treatments mainly include maximal surgical resection, radiotherapy, and chemotherapy, but these treatments often lead to long...
Optogenetic Inhibition of Insular Cortex Glutamatergic Neurons Regulates Trigeminal Neuropathic Pain Introduction and Background Trigeminal neuropathic pain (TNP) is a severe facial disorder characterized by rapid and intense stabbing pain attacks that spread along the cutaneous segments of the trigeminal nerve. TNP occurs almost twice as frequentl...