Choline Phosphate-Based Antigen Capture Strategy Boosts In Situ Tumor Vaccine Research: A Novel Immunotherapy Approach In the field of cancer immunotherapy, in situ tumor vaccines have garnered significant attention for their ability to harness a patient’s immune system to target tumors. However, challenges remain in their clinical application. To ...
Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...
Targeting CD70 with iPSC-Derived CAR-NK Cell Therapy Background and Objectives of the Study Over the past decade, cellular therapy for cancer has revolutionized traditional treatment concepts by introducing the idea of a “living drug.” In particular, chimeric antigen receptor T cell (CAR-T) therapy has drastically improved the efficacy of immunothe...
Research Report: Mitochondrial Uncouplers Inhibit E2F1 Activity and Prostate Cancer Growth Background Prostate cancer (PC) is the most common cancer and the second leading cause of cancer-related deaths among men in the United States. In 2024, an estimated 299,010 American men will be diagnosed with prostate cancer, and 35,250 will die from the dis...
Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the deposition of β-amyloid (Aβ) plaques and the aggregation of hyperphosphorylated microtubule-associated protein tau (tau). These pathological changes lead to gra...
Academic Background and Problem Statement Neurogenic Heterotopic Ossification (NHO) is a pathological condition where ectopic bone tissue forms in muscles following severe central nervous system (CNS) injuries, such as spinal cord injury (SCI), traumatic brain injury (TBI), or stroke. NHO not only impairs motor function but can also lead to joint s...
Study on the Association Between Long-Term Cancer Risk and Epigenetic Age in Stroke Survivors Background and Significance Cancer and stroke are leading global causes of morbidity and mortality, with their association being increasingly recognized. Statistics show that about 6% of cancer patients experience a stroke during their lifetime, while stro...
Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...
Research Report on Efferocytosis Features and Their Prognostic and Immunotherapy Associations in Lung Adenocarcinoma Background and Research Motivation Lung cancer is a leading cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) being the most common histological subtype. Due to the insidious nature of the disease and lack ...
Tumor Analysis of BRCA1/2 Carriers: Genomic Similarities Evident Across Different Time Points Breast cancer (BC) is the most common malignant tumor among women globally, with its pathogenesis predominantly sporadic, while familial hereditary cases account for only 5% to 10%. Among various pathogenic molecules, mutations in the BRCA1/2 genes (Pathog...