Application of Functional Ultrasound Imaging in the Study of the Human Spinal Cord Background Introduction The spinal cord is an important center for sensory and motor integration in the nervous system, responsible for monitoring the kinematics and posture of various body parts. Interruption of spinal cord information flow due to injury or disease ...

Background Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, regulating neuronal activity and plasticity through two distinct modes: phasic and tonic. However, our understanding of the mechanisms and physiological functions of GABA transmission in glial cells remains limited. Glial cells, especially astrocytes, ca...

Glucocorticoids Alter Human Cortical Neurogenesis by Regulating ZBTB16 Expression Background Introduction During pregnancy, glucocorticoids (GCs) are crucial steroid hormones for the development of the central nervous system (CNS). GCs regulate the development of fetal organs, particularly the lungs and brain. However, when GC levels exceed the phy...

Astrocytes Secrete Neurocan to Control Inhibitory Synapse Formation and Function In recent years, the role of neuron-glial cell interactions in synapse formation and maintenance of synaptic function has become a hot topic in neuroscience research. This paper, published by Dolores Irala et al. from Duke University Medical Center in the May 2024 issu...

Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...

Interactive Mechanisms Between Cancer Cells and Macrophages Facilitate Pancreatic Cancer Cachexia Background Pancreatic cancer is currently the third leading cause of cancer-related death in the United States and is expected to become the second leading cause of cancer death within the next decade. Unfortunately, more than 80% of pancreatic cancer ...

Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer Authors Ningning Niu, Qingshen Xu, Wang Zheng, …, Kurong Jiang, Fengshi Yu, Xue Xu Jing published an article titled “Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts He...

Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...

Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells Academic Background Checkpoint inhibitors (CPIs) have revolutionized cancer treatment by blocking immune regulatory signals mediated by checkpoint molecules, restoring T cell-mediated tumor clearance. However, these therapies also lead to a range of immune-related adverse events (IRAEs), wi...