Parkinson’s Disease (PD) is a neurodegenerative disease primarily characterized by dopaminergic neuron damage. Aside from causing motor disorders, over 80% of Parkinson’s disease patients also suffer from sleep disorders. Fragmented sleep is a common type of sleep disturbance among PD patients. It is associated not only with sleep maintenance insom...
Research Report: Predictive Role of Cerebrospinal Fluid Routine Parameters in the Disease Process of Multiple Sclerosis Background Multiple Sclerosis (MS) is characterized by a highly variable and unpredictable disease course. In the diagnosis of MS, cerebrospinal fluid (CSF) analysis is often a standard procedure. However, there has been ongoing d...
The Opening of the Blood-Brain Barrier in the Nigrostriatal System in Parkinson’s Disease Research Background Parkinson’s disease is a neurodegenerative disorder characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopaminergic transmission in the striatum. Currently, there are...
This is a multicenter retrospective cohort study on the impact of oral corticosteroid dosage and tapering duration on the time to first relapse in patients with initial presentation of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Background: MOGAD is a unique antibody-associated demyelinating disease. In both children an...
Circuit-Based Neuromodulation Enhances Delayed Recall Ability in Patients with Mild Cognitive Impairment Introduction As the aging population increases, amnestic mild cognitive impairment (AMCl) is receiving more attention. AMCl is seen as an important transitional stage from normal cognitive function to dementia and is a hotspot for studying cogni...
This research explores the clinical value of plasma phosphorylated tau proteins (p-tau) 217 and 181 in assessing patients with mild cognitive impairment. Mild cognitive impairment may be a precursor stage of Alzheimer’s disease (AD), and early detection and monitoring of disease progression are crucial for disease management. Research Background: A...
This is a large-scale prospective cohort study on depression in patients with Parkinson’s disease (PD). Researchers have used the vast cohort data from the UK Biobank to investigate the temporal association between depression and the onset of PD, the relationship between depression and brain region structure in PD patients, and the impact of depres...
Age-related hearing loss is considered a modifiable risk factor for dementia. However, the relationship between hearing, neurodegenerative changes, and cognitive changes, as well as how pathological processes such as Alzheimer’s disease and cerebrovascular disease affect these relationships, is not yet well understood. This report details a study o...
Epidemiological Study of Intimate Partner and Domestic Violence-Related Traumatic Brain Injuries in the United States from 2018-2021 Background Intimate partner violence (IPV) and domestic violence (DV) have severe medical, social, and legal consequences for victims. These violent events often result in traumatic brain injuries (TBIs), further exac...
This study explored the value of arterial wall enhancement grading on magnetic resonance imaging in predicting disease progression of moyamoya disease. This was a single-center retrospective cohort study that included 48 patients diagnosed with moyamoya disease who underwent arterial wall imaging and digital subtraction angiography follow-up. The s...