Venous Compression Causes Chronic Cerebral Ischaemia in Normal Pressure Hydrocephalus Patients

Chronic Cerebral Ischemia and Its Association with Normal Pressure Hydrocephalus Academic Background Normal Pressure Hydrocephalus (NPH) is a potentially reversible dementia characterized by cognitive impairment, gait disturbance, and urinary incontinence. Despite only a mild increase in intracranial pressure (ICP, approximately 15 mmHg), patients ...

Breaking Boundaries: Role of the Brain Barriers in Metastatic Process

The Role of Brain Barriers in Brain Metastasis Background Introduction Brain metastases (BMs) are the most common intracranial tumors in adults, occurring 3 to 10 times more frequently than primary brain tumors. Despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy, the prognosis for brain metastases remains poo...

Transmantle Pressure Under the Influence of Free Breathing: Non-Invasive Quantification of the Aqueduct Pressure Gradient in Healthy Adults

Non-invasive Quantification of Cerebrospinal Fluid Dynamics and Ventricle-Subarachnoid Space Pressure Gradient Background Cerebrospinal fluid (CSF) is a vital component of the central nervous system, providing protection to brain tissue, maintaining intracranial pressure stability, and facilitating the clearance of metabolic waste. Abnormal CSF cir...

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...

The Utility of Customised Tissue Probability Maps and Templates for Patients with Idiopathic Normal Pressure Hydrocephalus: A Computational Anatomy Toolbox (CAT12) Study

Improving the Accuracy of Brain Image Analysis in Patients with Idiopathic Normal Pressure Hydrocephalus Using Customized Tissue Probability Maps and Templates Academic Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a common neurological disorder characterized by gait disturbance, cognitive decline, and urinary incontinence. One of t...

A Novel Method to Study CSF Flow and BOLD Coupling Using Real-Time Phase Contrast Interleaved with Cortical BOLD MRI

New Method for Studying the Coupling Between Cerebrospinal Fluid Flow and Cortical BOLD Signals Academic Background In recent years, the role of cerebrospinal fluid (CSF) in brain waste clearance has garnered significant attention. Traditionally, CSF was thought to primarily serve as a cushion and provide immune surveillance. However, growing evide...

Choroid Plexus Aging: Structural and Vascular Insights from the HCP-Aging Dataset

Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...

Lumped Parameter Simulations of Cervical Lymphatic Vessels: Dynamics of Murine Cerebrospinal Fluid Efflux from the Skull

Numerical Simulation Study of Cerebrospinal Fluid Drainage through Cervical Lymphatic Vessels Background Introduction Cerebrospinal fluid (CSF) is a clear fluid that circulates around the brain and spinal cord, providing physical protection, nutrient supply, and waste clearance for the central nervous system. In recent years, growing evidence sugge...

Development and Application of an Automated In Vitro Model for Hydrocephalus Research

Application of Automated In Vitro Models in Hydrocephalus Research Background Introduction Hydrocephalus is a neurological condition caused by the accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles. If left untreated, it can lead to severe complications and permanent brain damage. It is estimated that 1 in every 500 newborns is bor...

Numerical Study of the Effects of Minor Structures and Mean Velocity Fields in the Cerebrospinal Fluid Flow

Study on Cerebrospinal Fluid Flow Dynamics and Its Application in Drug Delivery Background Introduction Cerebrospinal fluid (CSF) plays a crucial role in the human spinal canal, responsible for transporting dissolved nutrients and waste products. Due to its pulsatile nature, CSF flow is influenced by cardiac and respiratory cycles. In recent years,...