New Scientific Discovery: The 5:2 Intermittent Fasting Regimen Improves Non-Alcoholic Steatohepatitis and Reduces Hepatocellular Carcinoma Occurrence Research Background and Problem Statement Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with its prevalence increasing alongside rising obesity rates. N...
Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...
Browning of Subcutaneous White Adipose Tissue and Skin Repair Efficiency Current scientific research reveals that the participation of various cells is essential in the process of skin repair and regeneration. Among these, adipocytes (fat cells) have attracted attention due to their primary role in energy storage and critical endocrine functions in...
Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...
Study Report on White Matter Microstructure Changes in Adult-Onset Idiopathic Focal Cervical Dystonia Patients Scientists are dedicated to studying Adult-Onset Idiopathic Focal Cervical Dystonia (AOIFCD), the most common type of idiopathic dystonia in adults. This condition primarily manifests as abnormal neck muscle postures, often accompanied by ...
Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...
Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...
Clinical, Histopathological, and Genetic Characterization: Insights from Myofibrillar and Distal Myopathies Patients in the Italian Network Background and Research Motivation Myofibrillar Myopathies (MFM) and Distal Myopathies (DM) are a group of rare diseases with complex pathological presentations. The diagnosis process is extremely complicated d...
Abnormalities in Fetal Brain MRI in Pyruvate Dehydrogenase Complex Deficiency Background and Research Objective Pyruvate Dehydrogenase Complex Deficiency (PDCD) is a mitochondrial metabolic disorder caused by pathogenic variants in multiple genes, including PDHA1. Classic neonatal brain imaging features have been described, mainly focusing on devel...
Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...