Association between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults without Dementia: A Population-Based Cross-Sectional Analysis

Association Between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults: A Research Study Academic Background With the increasing global aging population, the number of dementia patients is rising annually. Early identification of older adults with declining cognitive function and guiding them toward preventive and thera...

Brain Endothelial Permeability, Transport, and Flow Assessed Over 10 Orders of Magnitude Using the In Situ Brain Perfusion Technique

Assessment of Brain Endothelial Permeability, Transport, and Flow Background Introduction The blood-brain barrier (BBB) is a critical barrier that protects the brain from harmful substances while also serving as a key obstacle for drug delivery to the brain. The permeability and transport properties of the BBB directly influence the distribution of...

Role of the Transcription Factor Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier

The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...

Non-invasive MRI of blood-cerebrospinal fluid-barrier function in a mouse model of Alzheimer’s disease: a potential biomarker of early pathology

Non-invasive MRI Study of Blood-Cerebrospinal Fluid Barrier Function in a Mouse Model of Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles. Recent studies have increasingly shown that the Blood-Cerebrospinal ...

Phase-Contrast MRI Analysis of Cerebral Blood and CSF Flow Dynamic Interactions

Study on the Interaction Between Cerebral Blood Flow and Cerebrospinal Fluid Dynamics Measured at Intracranial and Extracranial Planes Background The interaction between cerebral blood flow (CBF) and cerebrospinal fluid (CSF) is a critical factor in maintaining intracranial pressure (ICP) stability. According to the Monro-Kellie doctrine, the intra...

Reduced Oxycodone Brain Delivery in Rats due to Lipopolysaccharide-Induced Inflammation: Microdialysis Insights into Brain Disposition and Sex-Specific Pharmacokinetics

The Impact of Inflammation on Brain Delivery of Oxycodone Academic Background Oxycodone is a widely used opioid analgesic with a unique property of being actively transported from the blood to the brain across the blood-brain barrier (BBB). This process is believed to be associated with the proton-coupled organic cation (H+/OC) antiporter system. H...

The Influence of Glioblastoma Differentiation on Blood-Brain Barrier Permeability

The Impact of Glioblastoma Differentiation on Blood-Brain Barrier Permeability Background Introduction Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor, and its treatment is extremely challenging due to its complex biological characteristics and the presence of the Blood-Brain Barrier (BBB). The BBB is a complex structure composed o...

Relaxation-Exchange Magnetic Resonance Imaging (REXI): A Non-Invasive Imaging Method for Evaluating Trans-Barrier Water Exchange in the Choroid Plexus

Non-Invasive Imaging Technique for Evaluating Trans-Barrier Water Exchange in the Choroid Plexus Background Introduction The choroid plexus (CP) is a critical site for cerebrospinal fluid (CSF) production and an essential component of the blood-cerebrospinal fluid barrier (BCSFB). The CP regulates CSF secretion and absorption, maintaining brain hom...

Challenges to Mediterranean Fagaceae Ecosystems Affected by Phytophthora cinnamomi and Climate Change: Integrated Pest Management Perspectives

Challenges to Mediterranean Fagaceae Ecosystems Affected by Phytophthora cinnamomi and Climate Change Academic Background The Mediterranean Fagaceae ecosystems, including oak trees (Quercus ilex and Quercus suber) and chestnut trees (Castanea sativa), are vital ecological and economic resources in southern Europe. However, in recent years, these ec...

Global Synthesis of Quantification of Fire Behaviour Characteristics in Forests and Shrublands: Recent Progress

Global Progress in Quantifying Fire Behavior Characteristics in Forests and Shrublands Academic Background Wildland fire is a complex natural phenomenon involving interactions among chemical, physical, and biological processes. Due to its free-spreading nature, destructive energy fluxes, and hazardous environment, studying wildland fire is highly c...