Parkinson’s disease (PD) is a common neurodegenerative disorder characterized mainly by resting tremor, bradykinesia, and rigidity. Deep Brain Stimulation (DBS) has been widely used to treat the motor symptoms of PD (Krauss et al., 2021). However, DBS treatment also has significant side effects, most of which are caused by the extension of stimulat...
Research Background and Purpose Epilepsy is a spontaneous and severe neurological disorder characterized by recurrent seizures, affecting approximately 50 million people worldwide [1]. Despite recent advances in anti-seizure medications (ASMs), drug-resistant epilepsy (DRE) still affects 20% to 30% of epilepsy patients [1-3]. DRE patients face sign...
This paper is a study on the phenotypic associations and neurobiological bases of single-subject morphological brain networks. Combining multimodal and multiscale data, this study reveals the differences in morphological brain networks between genders, their potential as individual-specific markers, and their relationships with gene expression, lay...
Study of Network Information Interactions in Schizophrenia Magnetoencephalograms Based on Permutation Transfer Entropy Academic Background Schizophrenia (SCZ) is a mental disorder characterized by persistent delusions and hallucinations, disorganized thinking, and inconsistent behavior, often leading to significant impairment in the perception of r...
Brain Functional Network for Anxiety Analysis and Detection Based on Improved Ensemble Empirical Mode Decomposition Academic Background and Research Objectives With the increasing stress of modern life, anxiety, a common neurological disorder, has become an urgent issue in global public health. Anxiety not only manifests as mental disorders but als...
The Impact of Amplitude and Phase-based MRI Time Series on Functional Connectivity Analysis Introduction Over the past decade, functional magnetic resonance imaging (fMRI) has emerged as a non-invasive imaging technique that uses blood oxygen level-dependent (BOLD) contrast to measure brain activity and study brain function (Kwong, 1996). By analyz...
Spatio-Temporal Responses of Emotional Conflict and Psychiatric Correlation in Adolescent Epilepsy Patients Research Background Epilepsy patients often experience comorbid mental disorders such as depression and anxiety, which negatively impact their quality of life. Emotional regulation is a critical cognitive process that is frequently impaired i...
The Role of EEG Microstates in Predicting the Therapeutic Outcomes of Oxcarbazepine in Newly Diagnosed Focal Epilepsy Patients Introduction Background Focal epilepsy is the most common type of epilepsy, accounting for about 60% of all epilepsy cases. The selection of antiepileptic drugs (AEDs) varies depending on the type of epilepsy. In the treatm...
The Mechanism of Action of Specific Reprogramming of Histone H3 Lysine 9 Acetylation (H3K9ac) in the Progression and Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) Background Esophageal cancer is one of the most prevalent and invasive malignant tumors globally, causing over 500,000 cancer-related deaths annually, ranking sixth among cancer...
The research team consisting of Guilan Shi, Jody Synowiec, Julie Singh, and Richard Heller published a paper titled “Modification of the tumor microenvironment enhances immunity with plasmid gene therapy” in Cancer Gene Therapy. The background of the study stems from current challenges in the field of tumor immunotherapy, such as tumor cells evadin...