Research Progress on Programmable Topological Photonic Chips Research Background In recent years, topological insulators (TI) have garnered significant attention in the physics community due to their rich physical mechanisms and the potential applications of topological boundary modes, leading to rapid development in this field. Since the discovery...
Study on Chirality Transfer in Liquid Crystal Viruses Chirality is a phenomenon commonly found in nature and holds significant influence in various fields such as biology, chemistry, physics, and materials science. However, the mechanism of chirality transfer from nanoscale building blocks to macroscopic helical structures remains an unsolved myste...
Unique Patterns of Glycosylation in Plaques and Microglia in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is the most common form of dementia and a devastating neurodegenerative disorder. AD is characterized by two pathological features: extracellular β-amyloid (Aβ) plaques and intracellular phosphorylated Tau neurofibrillary ta...
Study on Cerebral Amyloid Angiopathy (CAA) and the Level of Tight Junction Protein Claudin-5 in Microvessels Background Cerebral Amyloid Angiopathy (CAA) is a disease caused by the deposition of Amyloid-β (Aβ) in the cerebral blood vessels. Research indicates that approximately 23% of individuals over the age of 55 have moderate to severe CAA. CAA ...
Neuroimaging and Molecular Markers in Alzheimer’s Disease: Data-Driven Meta-Analysis Research Background Alzheimer’s Disease (AD) is a chronic neurodegenerative disease characterized mainly by progressive memory loss and cognitive impairment, making it the most common type of dementia. Neuronal loss, one of the primary hallmarks of AD, is closely a...
Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps Maintain Respiratory Rate Under Sevoflurane Anesthesia Background Respiration is a core function for maintaining life activities. General anesthetics and/or opioids often suppress respiratory function. However, the respiratory suppression caused by the intravenou...
Whole-Brain Mapping of Specific Orbitofrontal Cortex Neuron Inputs and Outputs in Mice Research on the mouse brain has always been an important topic in neuroscience, especially studies on the orbitofrontal cortex (ORB). The ORB plays a key role in reward processing, decision making, behavioral flexibility, and emotional regulation. In recent years...
Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...
Background Introduction The brain is composed of different subtypes of neurons, which form complex neural networks through local and long-range synaptic connections. Understanding the functions of these neural networks requires knowledge of their connection patterns (projectome) and neuronal dynamics. Although advancements in mesoscale connectomics...
Thalamic Reuniens Nucleus Glutamatergic Neurons Mediated Colorectal Visceral Pain in Mice through 5-HT2B Receptors Background Irritable Bowel Syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is crucial for effectively alleviating abdominal pain in ...