Cardiovascular Disease and Breast Cancer Stage at Diagnosis

Association Between Cardiovascular Disease and Breast Cancer Stage at Diagnosis Academic Background Cardiovascular disease (CVD) and cancer are the two leading causes of mortality in the United States. Although they share many common risk factors, recent studies suggest that CVD may directly promote the occurrence and progression of cancer. Specifi...

Validation of the Online Collaborative Ocular Tuberculosis Study Calculator for Tubercular Uveitis

Academic Background Tubercular Uveitis (TBU) is an ocular condition caused by Mycobacterium tuberculosis infection or immune-mediated inflammation. While tuberculosis (TB) remains a major global public health issue, the diagnosis and treatment of TBU continue to pose significant challenges. TBU presents a wide range of clinical manifestations, with...

Curcuma-Based Nutritional Supplements and Risk of Age-Related Macular Degeneration

Report on Curcuma-Based Nutritional Supplements and the Risk of Age-Related Macular Degeneration Academic Background Age-related macular degeneration (AMD) is one of the leading causes of vision loss among elderly individuals, particularly in developed countries. There are two main types of AMD: non-exudative (dry) and exudative (wet). Dry AMD is c...

Economic Burden of Late-Stage Age-Related Macular Degeneration in Bulgaria, Germany, and the US

Report on the Economic Burden of Late-Stage Age-Related Macular Degeneration in Bulgaria, Germany, and the United States Academic Background Age-related macular degeneration (AMD) is a highly prevalent and debilitating retinal condition, affecting over 200 million people worldwide. Among them, late-stage AMD, which includes neovascular AMD (nAMD) a...

Racial Disparities in Genetic Detection Rates for Inherited Retinal Diseases

Racial Disparities in Genetic Detection Rates for Inherited Retinal Diseases Academic Background Inherited retinal diseases (IRDs) are a group of degenerative retinal disorders caused by genetic mutations, which can lead to vision loss or even blindness. With advances in gene discovery and next-generation DNA sequencing, an increasing number of pat...

Cataracts Associated with Fibroblast Growth Factor Receptor Inhibitors for Cholangiocarcinoma

Academic Background and Problem Statement Fibroblast growth factor receptor inhibitors (FGFRi) are a class of targeted drugs used to treat intrahepatic cholangiocarcinoma (iCCA). Although FGFRi has shown significant efficacy in treating iCCA, the potential complications associated with their long-term use have not been fully studied. In particular,...

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis Academic Background Primary open-angle glaucoma (POAG) is the most common form of glaucoma, often associated with elevated intraocular pressure (IOP). It is an irreversible optic neuropathy that, if untreated, can lead to vision loss. While IOP-lowering ...

Saliva of Persons with Hemophilia A Triggers Coagulation via Extrinsic Tenase Complexes

Extrinsic Tenase Complexes in Human Saliva Trigger Coagulation in Patients with Severe Hemophilia A Background Introduction Hemophilia A is a hereditary bleeding disorder caused by a deficiency or defect in clotting factor VIII (FVIII), inherited in an X-linked recessive pattern. Patients with severe hemophilia A often experience recurrent joint bl...

GSDME-mediated pyroptosis contributes to chemotherapy-induced platelet hyperactivity and thrombotic potential

Background Introduction Chemotherapy has long been a cornerstone of cancer treatment but is accompanied by significant side effects. Among cancer patients receiving platinum-based chemotherapy drugs (e.g., cisplatin), the incidence of thromboembolic events significantly increases, including pulmonary embolism, cerebrovascular incidents, angina, and...

Impact of Soluble BCMA and Non–T-Cell Factors on Refractoriness to BCMA-Targeting T-Cell Engagers in Multiple Myeloma

The Impact of Soluble B-Cell Maturation Antigen (sBCMA) on Multiple Myeloma Therapy: Interpreting the Latest Research Findings In recent years, cell-based immunotherapies have demonstrated enormous promise in the treatment of multiple myeloma (MM). Among these, BCMA-targeting T-cell engagers (TCEs) and chimeric antigen receptor (CAR) T-cell therapi...