Research Report: Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G, Exacerbating Sepsis Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The immune system dysfunction accompanying sepsis is primarily triggered by pathogen-associated molecular patterns (PAMPs) and damage-a...
Research Review: Treating Traumatic Brain Injury through Selective Inhibition of IL-6 Pathway Background Traumatic brain injury (TBI) is one of the leading causes of long-term neurological damage and death globally, with no effective disease-modifying treatments currently available. TBI patients often suffer from cognitive, behavioral, and sensory ...
Changes in Growth-Associated Protein 43 and Tensor-Based Morphometric Indicators in Mild Cognitive Impairment Research Background Alzheimer’s disease (AD) is a globally prevalent neurodegenerative disease whose incidence is expected to increase significantly in the coming years (Esquerda-Canals et al., 2017). The disease primarily manifests as defe...
Background Introduction In this paper, the researchers discuss the impact of aging on the functionality of all cell types in the central nervous system (CNS) and its role in neurological diseases such as multiple sclerosis (MS). However, the molecular mechanisms underlying these age-related changes and their contribution to diseases remain poorly u...
Research Report Titled “Comprehensive Evaluation of TDP-43 Neuropathology Data in the National Alzheimer’s Coordinating Center Database” Research Background TDP-43 proteinopathy is a significant neuropathological feature in frontotemporal lobar degeneration (FTLD-TDP), amyotrophic lateral sclerosis (ALS-TDP), and age-related limbic TDP-43 encephalo...
Study Report on Abnormal CHCHD2-Related Mitochondrial Pathology in Astrocytes in Kii ALS/PDC I. Research Background Amyotrophic lateral sclerosis/Parkinsonism-dementia complex (ALS/PDC) is a rare and complex neurodegenerative disorder primarily observed in Western Pacific islands such as Japan, Guam, and Papua New Guinea. Patients with this disease...
Research Background Multiple Sclerosis (MS) is a common disease involving lesions in the central nervous system, characterized mainly by demyelination of neuronal axons and neuronal damage. The heterogeneity of the disease is extremely high, meaning that different patients exhibit varying symptoms and pathological mechanisms, which greatly complica...
Co-localization of Gangliosides with Amyloid Beta Plaques in Alzheimer’s Disease Detected by MALDI-MSI and Histology Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and behavioral changes. Historically, AD research has focused on misfolded proteins, but with advancements in mass spectrometry...
Background The main purpose of this study is to investigate the distribution and diffusion patterns of tau protein in the early stages of Alzheimer’s disease, with a particular focus on the vulnerability of calretinin-positive neurons in the anterodorsal thalamic nucleus of the human subcortical region and the accumulation of tau pathology protein ...
Research Background In the field of neuroscience, amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two highly heterogeneous neurodegenerative diseases. Studies indicate that non-coding hexanucleotide repeat expansions in the c9orf72 gene are the most common genetic causes of these diseases. However, the specific ...