Research Background This study focuses on late-onset hypogonadism (LOH), aiming to uncover the mechanisms associated with age-related testicular function deviations, such as LOH, which are not yet fully understood. Utilizing single-cell RNA sequencing technology, the study analyzed the testicles of humans with LOH to identify supporting cells (SCs)...
Study on Human Muscle Aging Reveals Impact of Short-term Exercise on Lipid Composition Research Background As the global population ages, understanding the physiological changes associated with aging has become a key focus in scientific research. Previous studies using animal models have indicated that complex lipids, such as phospholipids, play im...
Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...
Research Background and Objectives With over 50 million people worldwide affected by cognitive impairment disorders, this number is expected to double by 2050. Alzheimer’s disease (AD) is the most common form of dementia, characterized by extracellular amyloid-beta (Aβ) plaques and intracellular tau protein aggregates in the brain. Over the past tw...
Plasma Proteomics Predicts the Future Risk of Dementia in Healthy Adults Background and Significance Predicting dementia has always been a significant challenge in the medical field. With the development of proteomics, biomarkers in the blood offer new opportunities for predicting the onset of dementia. This study focuses on data from the UK Bioban...
Achieving Synergistic Antitumor Activity by Dual Blocking of CCR1 and CXCR2 Expression in Myeloid Cells Background Introduction Colorectal Cancer (CRC) poses a global health crisis, with its incidence and mortality rates rapidly rising in recent years. Over the past 15 years, the mortality rate of CRC has increased by more than 30%, and it is expec...
Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...
The Path to Individualized Adjuvant Chemotherapy for All Four Types of Non-Pancreatic Periampullary Cancers: An International Multi-Method Cohort Study Background and Study Aim Although duodenal adenocarcinoma (DAC), intestinal type ampullary adenocarcinoma (AMPIT), pancreatobiliary type ampullary adenocarcinoma (AMPPB), and distal cholangiocarcino...
Research Report: Dominance and Persistence of T-Cell Clones in Tumor-Infiltrating Lymphocytes during Expansion in Breast Cancer Background Tumor-infiltrating lymphocytes (TILs) are lymphocytes that naturally infiltrate the tumor microenvironment and exhibit reactivity to the tumor. This subject is one of the most actively researched areas in tumor ...
Research Report on Comprehensive Genomic and Transcriptomic Characteristics of High-Grade Gastro-Entero-Pancreatic Neuroendocrine Tumors Research Background High-grade gastro-entero-pancreatic neuroendocrine neoplasms (HG GEP-NENs) are a heterogeneous group of malignant tumors characterized by neuroendocrine differentiation. According to WHO 2019 [...