Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: A role for netting neutrophils with resident memory T cells in situ

Stage-Dependent Immune Responses Mediated by AQP4 Antibodies in NMOSD Pathology in the Central Nervous System Academic Background Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune diseases of the central nervous system (CNS), characterized by the production of specific antibodies against the water channel protein Aquaporin-4 (AQP4). Al...

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease

Study of Tau Protein Accumulation in Brain Vasculature in Alzheimer’s Disease Background Introduction Alzheimer’s disease is characterized by neurodegeneration, with primary pathological features including amyloid plaques and neurofibrillary tangles (NFTs). These tangles are composed of tau protein, and these pathological changes are closely relate...

Ferroptosis Inhibitor Improves Outcome After Early and Delayed Treatment in Mild Spinal Cord Injury

Ferroptosis Inhibitors Improve Early and Delayed Treatment Outcomes of Mild Spinal Cord Injury Academic Background Spinal cord injury (SCI) causes significant secondary damage not only in the acute period but also in the chronic period. These injuries are typically triggered by multiple factors, including oxidative stress, inflammatory response, an...

Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease

Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...

Characteristics of the Structural Connectivity in Patients with Brain Injury and Chronic Health Symptoms: A Pilot Study

Study on Structural Connectivity Characteristics in Patients with Brain Injury and Chronic Health Symptoms Academic Background Traumatic Brain Injury (TBI) is one of the leading causes of post-traumatic death and disability. Even mild to moderate TBIs can result in a complex cluster of symptoms known as “post-concussion syndrome,” which includes he...

A Bayesian Multiplex Graph Classifier of Functional Brain Connectivity Across Diverse Tasks of Cognitive Control

Functional Brain Connectivity Research Using Bayesian Multiplex Graph Classifier Research Background and Problem Statement In recent years, research on cognitive control in the elderly has garnered increasing attention, especially against the backdrop of accelerating population aging. Understanding cognitive functions in the elderly becomes particu...

Utilizing fMRI to Guide TMS Targets: The Reliability and Sensitivity of fMRI Metrics at 3T and 1.5T

Utilizing fMRI to Guide TMS Targets: The Reliability and Sensitivity of fMRI Metrics at 3T and 1.5T

Using fMRI to Guide TMS Target Selection: Reliability and Sensitivity of 3T and 1.5T fMRI Metrics [DOI: 10.1007/s12021-024-09667-5], published in Neuroinformatics Background Introduction The early application of functional magnetic resonance imaging (fMRI) mainly focused on inferring cognitive processes. However, modern medicine is gradually extend...

Enhanced Spatial Fuzzy C-Means Algorithm for Brain Tissue Segmentation in T1 Images

Research Report on the Enhanced Spatial Fuzzy C-Means Algorithm for Brain Tissue Segmentation Academic Background Magnetic Resonance Imaging (MRI) plays a vital role in neurology, particularly in the precise segmentation of brain tissue. Accurate tissue segmentation is crucial for diagnosing brain injuries and neurodegenerative diseases. Segmenting...

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

ADAM10-Mediated Human Prion Protein Cleavage and Its Relationship with Neurodegenerative Diseases Background The endopeptidic processing of multifunctional proteins is crucial for regulating their physiological functions and plays a significant role in various pathological conditions. Prion protein (PrP), a widely expressed glycosylphosphatidylinos...

Identification of Retinal Oligomeric, Citrullinated, and Other Tau Isoforms in Early and Advanced AD and Relations to Disease Status

Research Report on Abnormal Tau Proteins in the Retina of Alzheimer’s Disease Patients Introduction Alzheimer’s disease (AD) is the primary cause of dementia in the elderly population worldwide. The pathological features of AD include the deposition of amyloid beta-protein (Aβ) and the aggregation of abnormal microtubule-associated tau proteins in ...