Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...

Study on Structural Connectivity Characteristics in Patients with Brain Injury and Chronic Health Symptoms Academic Background Traumatic Brain Injury (TBI) is one of the leading causes of post-traumatic death and disability. Even mild to moderate TBIs can result in a complex cluster of symptoms known as “post-concussion syndrome,” which includes he...

Functional Brain Connectivity Research Using Bayesian Multiplex Graph Classifier Research Background and Problem Statement In recent years, research on cognitive control in the elderly has garnered increasing attention, especially against the backdrop of accelerating population aging. Understanding cognitive functions in the elderly becomes particu...

Using fMRI to Guide TMS Target Selection: Reliability and Sensitivity of 3T and 1.5T fMRI Metrics [DOI: 10.1007/s12021-024-09667-5], published in Neuroinformatics Background Introduction The early application of functional magnetic resonance imaging (fMRI) mainly focused on inferring cognitive processes. However, modern medicine is gradually extend...

Research Report on the Enhanced Spatial Fuzzy C-Means Algorithm for Brain Tissue Segmentation Academic Background Magnetic Resonance Imaging (MRI) plays a vital role in neurology, particularly in the precise segmentation of brain tissue. Accurate tissue segmentation is crucial for diagnosing brain injuries and neurodegenerative diseases. Segmenting...

ADAM10-Mediated Human Prion Protein Cleavage and Its Relationship with Neurodegenerative Diseases Background The endopeptidic processing of multifunctional proteins is crucial for regulating their physiological functions and plays a significant role in various pathological conditions. Prion protein (PrP), a widely expressed glycosylphosphatidylinos...

Research Report on Abnormal Tau Proteins in the Retina of Alzheimer’s Disease Patients Introduction Alzheimer’s disease (AD) is the primary cause of dementia in the elderly population worldwide. The pathological features of AD include the deposition of amyloid beta-protein (Aβ) and the aggregation of abnormal microtubule-associated tau proteins in ...

Cross-Comparative Study of DNA Methylation Patterns in the Frontal Lobe White Matter of Multiple System Atrophy, Parkinson’s Disease, and Progressive Supranuclear Palsy Academic Background Multiple System Atrophy (MSA) is a rare neurodegenerative disease characterized by neuronal loss and gliosis, accompanied by glial cytoplasmic inclusions (GCIs) ...

Background Introduction Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by the death of neurons in the brain. Its main pathological features include extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs). β-amyloid plaques are primarily composed of aggregated Amyloid beta peptides (Aβ). A...

Gender Differences in Acute Axonal Pathology Following Experimental Concussion Academic Background Each year, approximately 50 million people worldwide suffer from concussions, also known as mild traumatic brain injuries (TBI). However, for more than 15% of patients, this “mild” brain injury can lead to lasting neurocognitive dysfunction. The exist...