Mechanism of RASAL1 and PTEN Co-Alterations Promoting Cancer Aggressiveness Academic Background Cancer is one of the leading causes of death worldwide, and its occurrence and progression involve abnormalities in multiple genes and signaling pathways. The PI3K-AKT signaling pathway plays a crucial role in cancer, and its overactivation is closely re...
TSH/TSHR Signaling Promotes CD8+ T Cell Exhaustion and Immune Evasion in Colorectal Cancer Background Colorectal cancer (CRC) is one of the most common malignancies worldwide with high morbidity and mortality rates. Although immune checkpoint blockade (ICB) therapy has shown significant efficacy in some patients, the majority of CRC patients, parti...
SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction Research Background Osteoporosis is a common bone disease characterized by reduced bone density and disrupted bone microstructure, leading to an increased risk of fractures. Osteoclasts, the primary cells responsible for bone resorption, play a cri...
The Role of Sirtuins in Obesity and Osteoporosis and Their Therapeutic Potential Academic Background Obesity and osteoporosis (OP) are increasingly severe public health issues worldwide. Obesity is not only closely related to metabolic diseases such as cardiovascular diseases and diabetes but also has a complex association with the occurrence of os...
The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...
Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...
Report on the Management of Chinese Older Adults with Type 2 Diabetes through Couple-Based Interventions: A Randomized Clinical Trial Academic Background Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic diseases globally, particularly common among older adults. China has the largest number of diabetes patients worldwide, reachin...
Diagnostic Accuracy and Value of 68Ga-Pentixafor PET/MRI in Tumor Localization for Cushing’s Disease Academic Background Cushing’s disease is the primary cause of Cushing’s syndrome, characterized by excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, often due to pituitary adenomas. Patients with chronic hypercortis...
Revolutionary Self-Powered Glucose Monitoring Mechanism: Microengineered Paper-Based Platform with Microbial Spores Academic Background Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications such as cardiovascular diseases, retinopathy, kidney failure, and neuropathy. The glob...
Academic Background Metabolic-associated Steatotic Liver Disease (MASLD) is a major health issue affecting over 30% of the global population and is closely related to various chronic diseases such as cancer, cardiovascular disease, and renal dysfunction. The pathological spectrum of MASLD ranges from simple steatosis to steatohepatitis and progress...