Preventing Diabetic Cardiomyopathy through Suppressing TGR5-Mediated Fatty Acid Uptake Background and Problem Statement Diabetic Cardiomyopathy (DBCM) is a severe complication frequently faced by diabetic patients, characterized by lipid accumulation in the myocardium and cardiac dysfunction. Bile acid metabolism plays a crucial role in cardiovascu...

Microbial Metabolite Ethylamine as FXR Agonist Promotes Polycystic Ovary Syndrome in Female Mice I. Research Background and Objectives Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting 6%-20% of women of reproductive age worldwide. Symptoms of PCOS include hyperandrogenemia, ovarian dysfunction, and polycystic ...

The Coordinating Role of the Hippo-YAP/TAZ Pathway in Adipose Plasticity and Energy Balance Adipose tissue not only serves as an energy storage depot but also functions as an endocrine organ. However, the mechanisms coordinating these functions remain elusive. This study unveiled that the transcriptional co-regulators YAP and TAZ maintain metabolic...

Integrated Analysis of Blood DNA Methylation, Genetic Variation, Circulating Proteins, microRNAs, and Kidney Failure in Type 1 Diabetes Research Background Diabetic Kidney Disease (DKD) is one of the major complications of Type 1 Diabetes (T1D). Approximately 40% of T1D patients develop DKD, and 10% to 15% eventually progress to Kidney Failure (KF)...

Utilization of Lipid Nanoparticles-mRNA Formulations to Eliminate ROS and Accelerate Diabetic Wound Healing Diabetic wounds are common complications in patients with hyperglycemia, characterized by high incidence and recurrence rates, causing substantial global economic losses. Existing treatments, including wound offloading and growth factor thera...

GLP-1-Directed NMDA Receptor Antagonism for Obesity Treatment In recent decades, obesity has become a global health problem, seriously affecting the quality of life and health of millions of people. Obesity is not only associated with numerous health issues such as diabetes, hypertension, and cardiovascular diseases but also severely impacts mental...

This is a report on the 55-year follow-up of the first case of a craniopharyngioma patient who underwent gamma knife radiosurgery. The article details the medical history, diagnosis process, gamma knife surgery details, as well as the 55-year follow-up with multiple treatments, providing a comprehensive overview of the patient’s long medical journe...