Sustained Reduction of Essential Tremor with Low-Power Non-Thermal Transcranial Focused Ultrasound Stimulation in Humans Background Essential Tremor (ET) is one of the most common neurological disorders, primarily characterized by bilateral upper limb action tremor that persists for more than three years. For ET unresponsive to medication, neurosur...

Threshold and Mechanisms of Magnetophosphene Perception Background The effect of Magnetic Fields (MF) on the human body has long been a hot topic in scientific research. Extremely Low-Frequency Magnetic Fields (ELF-MF) are widespread in daily life, primarily originating from power lines (50⁄60 Hz) and household appliances. These magnetic fields can...

Patients with Parkinson’s Disease (PD) often experience gait impairments, which severely affect their quality of life. Previous studies have suggested that β-frequency (15-30 Hz) oscillatory activity in the basal ganglia may be associated with gait impairments, but the exact dynamics of these oscillations during the gait process remain unclear. Add...

The Intensity-Dependent Effects of Cortical Electrical Stimulation on Motor Learning and the Role of Dopamine Background Introduction Nowadays, non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) are widely used in neuroplasticity research to modulate cognition and behavior. However, optimizing stimulati...

Application of Non-Invasive Vagus Nerve Stimulation in Spontaneous Subarachnoid Hemorrhage: A Randomized Safety and Feasibility Study Report Spontaneous subarachnoid hemorrhage (SAH) is often accompanied by severe thunderclap headaches, which patients typically describe as the “worst headache of their lives.” The vast majority of patients (90%) con...

Unique Patterns of Glycosylation in Plaques and Microglia in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is the most common form of dementia and a devastating neurodegenerative disorder. AD is characterized by two pathological features: extracellular β-amyloid (Aβ) plaques and intracellular phosphorylated Tau neurofibrillary ta...

Study on Cerebral Amyloid Angiopathy (CAA) and the Level of Tight Junction Protein Claudin-5 in Microvessels Background Cerebral Amyloid Angiopathy (CAA) is a disease caused by the deposition of Amyloid-β (Aβ) in the cerebral blood vessels. Research indicates that approximately 23% of individuals over the age of 55 have moderate to severe CAA. CAA ...

Neuroimaging and Molecular Markers in Alzheimer’s Disease: Data-Driven Meta-Analysis Research Background Alzheimer’s Disease (AD) is a chronic neurodegenerative disease characterized mainly by progressive memory loss and cognitive impairment, making it the most common type of dementia. Neuronal loss, one of the primary hallmarks of AD, is closely a...

Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...

TDRD3 Deficient Mice Exhibit Deficits in Neurogenesis and Synaptic Plasticity at Both Post-transcriptional and Behavioral Levels Research Background Topoisomerase 3b (top3b) is a dual-activity topoisomerase capable of resolving DNA and RNA topological problems. An increasing body of evidence indicates that top3b functions as a conserved complex wit...