APOE4 Homozygotes Represent a Unique Genotypic Subset of Alzheimer’s Disease Introduction Alzheimer’s disease (AD) is one of the neurodegenerative diseases that modern medicine has yet to conquer, usually with a complex genetic background. While mutations in three genes (APP, PSEN1, and PSEN2) lead to early-onset autosomal dominant Alzheimer’s dise...
The Gating Role of Cortical Transfer of Socially Derived Information in Emotion Recognition Background Introduction Emotion recognition and the subsequent responses are crucial for survival and maintaining social functions. However, how social information is processed to reliably recognize emotions remains unclear. In this new study, the authors re...
Differences in Coupling Between Cortical Networks Related to Arousal in Neural Activity and Hemodynamics Academic Background In the absence of specific sensory inputs or behavioral tasks, the brain generates structured activity patterns. This organized activity is modulated by the state of arousal. The relationship between arousal and cortical acti...
Using Monotonicity-Constrained Deep Geometric Learning to Predict Alzheimer’s Disease Progression Background Introduction Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that gradually leads to irreversible cognitive decline, eventually resulting in dementia. Early identification and progression prediction of this disease are c...
Parkinson’s Disease Research Report: Subthalamic Nucleus–Language Network Functional Connectivity Predicts Dopaminergic Modulation of Speech Function Background Parkinson’s disease (PD) is primarily characterized by motor impairments, but it also involves non-motor symptoms including speech disorders, severely affecting patients’ quality of life. A...
Academic News Report Background The motor cortex has long been the focus of research on motor control, mainly studying its role in active motor execution. However, even in the absence of actual motor output, the motor cortex also activates during motor imagery. Previous behavioral and imaging studies have confirmed this phenomenon, but how the spec...
Differentiating Visual and Semantic Information in Human Perception and Memory Using Deep Neural Networks Introduction In cognitive science, the study of how humans recognize individuals and objects during perception and memory processes has long been of interest. Successful recognition of people and objects relies on matching representations gener...
Academic News Report: Revealing Effector-Independent Evidence Accumulation Dynamics from Intracranial Electrophysiological Recordings Research Background The neural mechanisms underlying the decision-making process have long been a significant topic in neuroscience. Previous studies have indicated that it is possible to identify neural signals rela...
Predictive Autoantibody Signature for Multiple Sclerosis Academic Background and Research Significance Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease that primarily affects the white matter of the central nervous system (CNS). Previous studies have mostly suggested that T cells play a major role in the pathogenesis of MS. Howe...
Abstract In recent years, researchers have gradually recognized that contextual awareness and goal-directed responses to emotional events are crucial for adaptive functioning. Behavioral and emotional regulation models posit that the lateral prefrontal cortex (lpfc) maintains goal-related representations, thereby facilitating cognitive control. How...