Application of Functional Ultrasound Imaging in the Study of the Human Spinal Cord Background Introduction The spinal cord is an important center for sensory and motor integration in the nervous system, responsible for monitoring the kinematics and posture of various body parts. Interruption of spinal cord information flow due to injury or disease ...

Background Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, regulating neuronal activity and plasticity through two distinct modes: phasic and tonic. However, our understanding of the mechanisms and physiological functions of GABA transmission in glial cells remains limited. Glial cells, especially astrocytes, ca...

Glucocorticoids Alter Human Cortical Neurogenesis by Regulating ZBTB16 Expression Background Introduction During pregnancy, glucocorticoids (GCs) are crucial steroid hormones for the development of the central nervous system (CNS). GCs regulate the development of fetal organs, particularly the lungs and brain. However, when GC levels exceed the phy...

Astrocytes Secrete Neurocan to Control Inhibitory Synapse Formation and Function In recent years, the role of neuron-glial cell interactions in synapse formation and maintenance of synaptic function has become a hot topic in neuroscience research. This paper, published by Dolores Irala et al. from Duke University Medical Center in the May 2024 issu...

Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...

Leptomeningeal Glial Modulation of Ischemic Stroke Reperfusion to Avoid Futile Recanalization Background Ischemic Stroke is caused by the sudden blockage of cerebral arteries, leading to millions of disabilities and deaths globally each year. The current treatment for ischemic stroke primarily involves intravenous thrombolysis or mechanical thrombe...

Multi-template Meta-information Regularized Network for Alzheimer’s Disease Diagnosis: A Study Based on Structural MRI Research Background Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, and its diagnosis and early detection is a significant challenge in the medical field. Structural MRI (sMRI) is widely used in computer-aided...

Remote Gait Analysis Using Ultra-Wideband Radar Technology Research Background Gait analysis, the study of the coordinated biomechanical patterns of human walking, is not only a critical component of biomechanics research but also provides valuable information on health status. In recent years, there has been a growing interest in developing new at...

Piezo1 and Piezo2 Mechanosensitive Ion Channels Regulate the Response of Rodents to Transcranial Focused Ultrasound Stimulation of the Motor Cortex Academic Background Transcranial Focused Ultrasound (TFUS) neuromodulation is a non-invasive, deep brain stimulation technique that shows great potential in the study of neural circuits and the treatmen...

Research on Quantitative Model for Freezing of Gait in Parkinson’s Patients Background Introduction Parkinson’s Disease (PD) is a common neurodegenerative disease, accompanied by complex motor disorders. In the later stages of Parkinson’s disease, the phenomenon of “Freezing of Gait” (FOG) becomes particularly prominent. FOG refers to a transient p...