Stage-Dependent Immune Responses Mediated by AQP4 Antibodies in NMOSD Pathology in the Central Nervous System Academic Background Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune diseases of the central nervous system (CNS), characterized by the production of specific antibodies against the water channel protein Aquaporin-4 (AQP4). Al...

Study of Tau Protein Accumulation in Brain Vasculature in Alzheimer’s Disease Background Introduction Alzheimer’s disease is characterized by neurodegeneration, with primary pathological features including amyloid plaques and neurofibrillary tangles (NFTs). These tangles are composed of tau protein, and these pathological changes are closely relate...

Ferroptosis Inhibitors Improve Early and Delayed Treatment Outcomes of Mild Spinal Cord Injury Academic Background Spinal cord injury (SCI) causes significant secondary damage not only in the acute period but also in the chronic period. These injuries are typically triggered by multiple factors, including oxidative stress, inflammatory response, an...

Original Title: 《Associations of CSF BACE1 with Amyloid Pathology, Neurodegeneration, and Cognition in Alzheimer’s Disease》 Background and Research Purpose Alzheimer’s Disease (AD) is a leading cause of dementia in the elderly, characterized by the accumulation of β-amyloid protein (Aβ) plaques in the brain. Beta-site APP cleaving enzyme 1 (BACE1) ...

The Influence of APOEε4 on the pTau Interactome in Sporadic Alzheimer’s Disease Background Alzheimer’s disease (AD) is a neurodegenerative disease characterized by extracellular deposition and aggregation of β-amyloid protein (Aβ) forming various types of Aβ deposits and the intracellular accumulation and assembly of abnormally phosphorylated tau p...

Study on Structural Connectivity Characteristics in Patients with Brain Injury and Chronic Health Symptoms Academic Background Traumatic Brain Injury (TBI) is one of the leading causes of post-traumatic death and disability. Even mild to moderate TBIs can result in a complex cluster of symptoms known as “post-concussion syndrome,” which includes he...

Innovative Fusion in Neuron Classification: Shared Information from Human and Mouse Electrophysiological Data The scientific community has long faced significant challenges in neuron classification. Accurate classification of neurons is crucial for understanding brain function in both healthy and diseased states. This study, led by Ofek Ophir, Orit...

A New Breakthrough in Neuroinformatics: Research Report on Cadence Tool for Calcium Event Detection Background Introduction Calcium imaging technology has revolutionized the study of neuron ensembles, providing researchers with a powerful tool to simultaneously visualize and monitor multiple neuronal activities. Calcium imaging utilizes fluorescent...

Functional Brain Connectivity Research Using Bayesian Multiplex Graph Classifier Research Background and Problem Statement In recent years, research on cognitive control in the elderly has garnered increasing attention, especially against the backdrop of accelerating population aging. Understanding cognitive functions in the elderly becomes particu...

Academic Background It is widely recognized that the cognitive function of patients with high-grade glioma is affected by the location and volume of the tumor. However, research on how to accurately predict individual patients’ cognitive function for personalized treatment decisions before and after surgery remains limited. Currently, most studies ...