New Gene Therapy Approach May Control Epileptic Seizures Caused by Focal Cortical Dysplasia Focal Cortical Dysplasia (FCD) is a type of disorder caused by abnormal cortical development, often accompanied by drug-resistant epilepsy and cognitive and behavioral disorders. According to the classification criteria proposed by Najm et al. in 2022 for th...
Study on MERTK Reducing Blood-Spinal Cord Barrier Permeability after Spinal Cord Injury via RhoA/ROCK1/p-MLC Pathway Spinal Cord Injury (SCI) is a central nervous system disease caused by trauma, inflammation, tumors, or other pathological reasons, resulting in sensory, motor, and autonomic nervous system dysfunction in patients, imposing a heavy b...
Mechanism Study of High Magnesium Promoting Binocular Vision Recovery in Amblyopia Patients: The Role of TRPM7 Abnormal visual experiences during critical periods of brain development can lead to visual function deficits, such as amblyopia. Current research suggests that high magnesium (Mg^2+) supplementation can restore synaptic plasticity in the ...
The Impact of Music Training on Language Perception in Older Adults Under Global Aging Challenges Research Background As global population aging accelerates, the decline in language perception ability of older adults in noisy environments has become a notable issue. Older adults, even with normal hearing, often encounter the “cocktail party problem...
Contemporary Anesthesia Safety Research: New Pathological Mechanism of Fine Motor Deficits in Mice With the advancement of modern anesthesia techniques, millions of lives rely on successful surgeries each year. However, various clinical studies, including those by the Mayo Anesthesia Safety in Kids (MASK) group, suggest that children who undergo mu...
Study on Quantitative Expression and Treatment Response of Latent Disease Factors Underlying Psychopathological Dimensions Revealed by Unsupervised Machine Learning Research Background Heterogeneity and comorbidity are prevalent in psychiatric diagnoses, posing challenges for precise diagnosis and personalized treatment. For instance, Autism Spectr...
Computational Modeling of Prefrontal-Cingulate Coupling: Exploring Its Role in Balancing Emotion and Cognition Academic Background In recent years, emotional processing and cognitive control, which are crucial for maintaining normal social behavior and executive function, have attracted widespread attention. This study explores how the balance betw...
Sexual Dimorphism in the Mouse Kidney-Brain Connectome In recent years, an increasing number of studies have shown that kidney function is not only influenced by local self-regulation and hormonal systems but is also largely regulated by the nervous system. Although it is known that there are multi-synaptic anatomical connections between central au...
Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...
Neural computational mechanisms underlying fairness-based decisions: Self-Unfairness and Other-Unfairness Abstract: Fairness is a fundamental value in human society, and individuals show concern for both self-unfairness and other-unfairness. However, there has been a long-standing debate on whether self-unfairness and other-unfairness evoke shared ...