Light/pH Dual Controlled Drug Release 'Nanocontainer' Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy

Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...

Temporal and Spatial Regulation of Biomimetic Vascularization in 3D-Printed Skeletal Muscles

Temporal and Spatial Regulation of Biomimetic Vascularization in 3D-Printed Skeletal Muscles

Application of 3D Printing Technology in Skeletal Muscle Vascularization Research Academic Background Skeletal muscle tissue is one of the most important tissues in the human body, and its function relies on the close relationship between myotubes and the vascular network. The vascular network not only supplies oxygen and nutrients to skeletal musc...

Crystalloid Volume Versus Catecholamines for Management of Hemorrhagic Shock During Esophagectomy: Assessment of Microcirculatory Tissue Oxygenation of the Gastric Conduit in a Porcine Model Using Hyperspectral Imaging

Study on Crystalloid Volume versus Catecholamine Strategies for Managing Hemorrhagic Shock during Esophagectomy Academic Background Esophageal cancer is a common malignant tumor worldwide, and surgical resection is one of the primary treatment methods. However, esophagectomy is a complex procedure involving two body cavities (thoracic and abdominal...

Treatment Patterns and Prognosis of Patients with Clear Cell Adenocarcinoma of the Cervix: A Population-Based Cohort Study

Treatment Patterns and Prognosis of Clear Cell Adenocarcinoma of the Cervix: A Research Study Academic Background Cervical cancer ranks as the fourth most common gynecological malignancy globally and the third leading cause of cancer-related mortality in women. Among its subtypes, clear cell adenocarcinoma of the cervix (CCAC) is an extremely rare ...

Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Utilizing Bifurcated Allogeneic Vein Grafts: A Novel Approach for Preventing Sinistral Portal Hypertension Following Pancreaticoduodenectomy. A 10-Year Before and After Study

Utilizing Bifurcated Allogeneic Vein Grafts to Prevent Sinistral Portal Hypertension Following Pancreaticoduodenectomy Academic Background Pancreatic cancer is a highly malignant tumor with a poor prognosis, with a 5-year survival rate of less than 10%. The early invasive growth of pancreatic cancer often involves the portal vein system, particular...

A 10-Year Mono-Center Study on Patients with Burns ≥70% TBSA: Prediction Model Construction and Multicenter Validation – Retrospective Cohort

Survival Prediction Model Construction and Validation for Patients with Major Burns Background Burns are the sixth leading cause of death from injuries globally, particularly for patients with major burns (≥70% total body surface area, TBSA), who face severe complications and poor prognosis. Despite advancements in burn treatment, there is still a ...

Pattern and Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma – A Case–Control Study Based on Liver Panoramic Digital Pathology

Study on the Pattern and Extent of Intrahepatic Infiltration in Perihilar Cholangiocarcinoma Academic Background Perihilar cholangiocarcinoma (PHCC) is one of the most common malignancies of the biliary system, and its treatment primarily relies on radical surgical resection. However, despite advancements in surgical techniques, the postoperative r...

Comparison of Long-Term Survival of Neoadjuvant Therapy Plus Surgery Versus Upfront Surgery and the Role of Adjuvant Therapy for T1b-2N0-1 Esophageal Cancer: A Population Study of the SEER Database and Chinese Cohort

Comparative Study on Treatment Strategies for Esophageal Cancer Academic Background Esophageal cancer is one of the digestive system tumors with high incidence and mortality rates worldwide, particularly in Asia, where the incidence of esophageal squamous cell carcinoma (SCC) is notably prominent. Although significant progress has been made in the ...

Global, Regional, and National Patterns of Change in the Burden of Nonmalignant Upper Gastrointestinal Diseases from 1990 to 2019 and the Forecast for the Next Decade

Trends and Future Predictions of the Global Burden of Non-Malignant Upper Gastrointestinal Diseases Academic Background Non-malignant upper gastrointestinal diseases, including Peptic Ulcer Disease (PUD), Gastritis and Duodenitis (GD), and Gastroesophageal Reflux Disease (GERD), pose significant challenges to global healthcare systems. These condit...