Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...

Spatiotemporal Imprinting of Tissue-Resident Memory CD8 T Cell Diversity Background Tissue-resident memory CD8 T cells (TRM cells) provide long-term immune protection at barrier sites such as the intestine. However, the heterogeneity of TRM cells and the mechanisms underlying their formation remain incompletely understood. Previous studies have ide...

Metabolic Rewiring Controlled by HIF-1α Tunes IgA-Producing B-Cell Differentiation and Intestinal Inflammation Background Introduction Germinal centers (GC) are critical sites for the clonal expansion of immune B cells and the affinity maturation of antibodies, as well as the occurrence of antibody class switching. Within the GC, B cells undergo so...

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

The Impact of CD30 on Germinal Center B Cell Dynamics and the Expansion of IgG1-Switched B Cells Background CD30 (also known as TNFRSF8) is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Initially identified as a marker of Hodgkin lymphoma, subsequent research revealed its expression on other lymphomas, such as diffuse large B-...

Critical Role of UBXN6 in Autophagy Induction and Inflammation Control in Macrophages Background The innate immune system serves as the first line of defense against pathogen invasion and inflammatory responses. Monocytes and macrophages, as key cell types in the innate immune system, play critical roles during infection and inflammation. However, ...

NUDT21 Regulates Macrophage Hyperactivation via the Autophagy Pathway Academic Background The inflammatory response is a critical component of the body’s immune defense, facilitating pathogen clearance and tissue repair. However, dysregulation of the inflammatory response can lead to chronic inflammatory diseases such as inflammatory bowel disease ...

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Osteochondral Abnormalities on Three-Dimensional Ultrashort Echo Time MRI Scans Are Associated with Knee Cartilage Degradation Academic Background Osteoarthritis (OA) is the most prevalent musculoskeletal disease, characterized by pain and disability. A hallmark of OA is the progressive loss of articular hyaline cartilage, which connects to the sub...