Sense of Presence in Virtual Reality: Exploration and Validation of Neurophysiological Markers Background Introduction In recent years, Virtual Reality (VR) technology has been widely applied in fields such as medicine, training, and rehabilitation. The core of VR lies in the user’s “sense of presence,” which refers to the immersive experience of “...
Unsupervised Accuracy Estimation for Brain-Computer Interfaces Based on Selective Auditory Attention Decoding Academic Background In complex auditory environments, humans can selectively focus on a specific sound source while ignoring other interfering sounds—a phenomenon known as the “cocktail party effect.” Selective Auditory Attention Decoding (...
Academic Background Parkinson’s Disease (PD) is the second most common chronic neurodegenerative disease, primarily affecting individuals aged 65 and above. With the global population aging, the prevalence of Parkinson’s disease is projected to increase from 7 million in 2015 to 13 million by 2040. Currently, the diagnosis of Parkinson’s disease ma...
A Quantitative Comparison Study of Electrode Positions for Respiratory Surface Electromyography Academic Background Respiratory surface electromyography (SEMG) is a non-invasive technique used to record the electrical activity of respiratory muscles. It is widely applied in analyzing respiratory effort, patient-ventilator asynchrony, and respirator...
O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-DOPA Levels Research Background In the nervous system, dopamine is a key neurotransmitter, and the rate-limiting enzyme in its synthesis pathway is tyrosine hydroxylase (TH). The activity of TH is regulated by various post-translational modifications (PTMs), among which ...
Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease via Endothelial LAG3 Endocytosis Academic Background Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the abnormal formation and transmission of α-synuclein (α-syn). Recent studies have ...
Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...
Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...
Syntaxin 4-Enhanced Plasma Membrane Repair is Independent of Dysferlin in Skeletal Muscle Background Introduction Plasma membrane repair (PMR) is a crucial process for cells to maintain membrane integrity, preventing cell death, especially in vital organs such as skeletal muscle. Dysferlin, a sarcolemmal calcium-binding protein, has been shown to p...
Functional Connectivity Analysis of Children with Autism under Emotional Stimulation Background Introduction Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, primarily characterized by deficits in social interaction and communication abilities, as well as repetitive behaviors and restricted interests. One of the core feature...