Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients with Traumatic Brain Injury

Medicine, Emergency Medicine, Medical Laboratory Science, Neurology, Medical Imaging,
prehospital lactate levels   traumatic brain injury   in-hospital mortality   Glasgow Coma Scale   emergency care  

Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...

Long-term Dementia Risk in Parkinson Disease

Medicine, Geriatrics, Neurology, Life Sciences,
Parkinson's disease   dementia risk   long-term study   cognitive impairment   neurological disorders  

Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...

Clinical, Histopathologic, and Genetic Features of Patients with Myofibrillary and Distal Myopathies: Experience from the Italian Network

Medicine, Respiratory System, Neurology, Cardiovascular System, Life Sciences, Genetics,
Myofibrillary Myopathies   Distal Myopathies   Clinical Features   Histopathologic Features   Genetic Features   Italian Network   Molecular Confirmation  

Clinical, Histopathological, and Genetic Characterization: Insights from Myofibrillar and Distal Myopathies Patients in the Italian Network Background and Research Motivation Myofibrillar Myopathies (MFM) and Distal Myopathies (DM) are a group of rare diseases with complex pathological presentations. The diagnosis process is extremely complicated d...

Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency

Medicine, Pediatrics, Obstetrics and Gynecology, Neurology, Medical Imaging,
Pyruvate Dehydrogenase   Complex Deficiency   Fetal MRI   Brain Abnormalities   Genetic Disorder   Second Trimester Diagnosis  

Abnormalities in Fetal Brain MRI in Pyruvate Dehydrogenase Complex Deficiency Background and Research Objective Pyruvate Dehydrogenase Complex Deficiency (PDCD) is a mitochondrial metabolic disorder caused by pathogenic variants in multiple genes, including PDHA1. Classic neonatal brain imaging features have been described, mainly focusing on devel...

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients with Intracranial Hemorrhage and Mechanical Heart Valves

Medicine, Neurology, Neurosurgery, Hematology, Cardiovascular System,
Anticoagulation   Ischemic Complications   Hemorrhagic Complications   Mechanical Heart Valves   Intracranial Hemorrhage  

Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Sex Differences in the Risk of Stroke Associated with Traditional and Non-Traditional Factors in a US Cohort of People with HIV Infection

Medicine, Infectious Diseases, Neurology, Cardiovascular System,
HIV   stroke   sex differences   cardiovascular risk   lifestyle factors   HIV viremia  

Study on Gender Differences and Stroke Risk Among HIV-Infected Individuals Background Individuals with HIV infection may face a higher risk of stroke, particularly women. However, understanding of whether the influence of various factors on cerebrovascular risk in this population differs by gender and whether these differences contribute to variati...

Associations of Microbleeds and Their Topography with Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals with Down Syndrome

Medicine, Psychiatry, Geriatrics, Neurology, Medical Imaging,
Down Syndrome   Microbleeds   Alzheimer's Disease   Biomarkers   Imaging  

Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...

Clinicopathologic and Neuroimaging Correlations of Nonverbal Oral Apraxia in Patients with Neurodegenerative Disease

Medicine, Basic Medical Sciences, Neurology, Medical Imaging,
Nonverbal Oral Apraxia   Neurodegenerative Disease   Clinicopathologic   Neuroimaging   Progressive Supranuclear Palsy   Corticobasal Degeneration  

Nonverbal Oral Apraxia in Patients with Neurodegenerative Diseases: Clinical-Pathological and Neuroimaging Correlations Research Background Nonverbal Oral Apraxia (NVOA) is a condition characterized by the inability to plan, sequence, and execute voluntary oral-facial movements without muscle weakness. NVOA was first identified in stroke patients, ...

Genetic Associations with an Amyotrophic Lateral Sclerosis Reversal Phenotype

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Amyotrophic Lateral Sclerosis   Reversal Phenotype   Genome-Wide Association Study   Gene Expression   IGFBP7  

Genetic Association Study of ALS Reversal Phenotype Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the death of upper and lower motor neurons, progressive weakness, and eventual respiratory failure. However, individual ALS patients have exhibited unusual clinical reversal phenomena, where symptoms signific...

Effect of Immunosuppression in Risk of Developing Generalized Symptoms in Ocular Myasthenia Gravis

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
immunosuppression   ocular myasthenia gravis   generalization   steroids   retrospective study  

The Effect of Immunosuppression on the Risk of Generalization in Ocular Myasthenia Gravis Background Ocular Myasthenia Gravis (OMG) is an early and localized manifestation of Myasthenia Gravis (MG), with many patients initially presenting with ocular symptoms such as fatigable ptosis and diplopia. Approximately 85% of MG patients initially exhibit ...