Targeted Delivery of Napabucasin with Radiotherapy in Diffuse Midline Glioma Background Introduction Diffuse Midline Glioma (DMG) is the most aggressive primary brain tumor in children, with a median survival typically less than one year. Although radiation therapy (RT) is the current standard treatment, it only provides transient symptom relief an...

Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma Academic Background Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant intratumoral heterogeneity, which is evident not only in gene expression and histopathology but also in macro...

Background Introduction The field of psychiatry has long relied on symptoms and medical interviews for diagnosis, lacking objective biomarkers. Resting-state functional magnetic resonance imaging (rs-fMRI) is widely believed to reveal characteristic patterns of brain structure and function, thereby providing potential classification markers for the...

Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...

Study on Peripheral Nerve Regeneration Based on Multi-Gradient MgO/MgCO₃/PCL Nanofiber Membranes Academic Background Peripheral nerve defects are a common and complex orthopedic issue in clinical practice, with limited efficacy of current treatments. The insufficient proliferation and dysfunction of Schwann cells within nerve scaffolds are key fact...

Academic Report on “Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study” Academic Background Mechanical ventilation (MV) is a fundamental component of the intensive care unit (ICU) management of acute brain injury (ABI) patients. However, strong evidence on the best ven...

Academic Background The regenerative capacity of the nervous system varies significantly between different regions. Axons in the peripheral nervous system (PNS) can regenerate spontaneously after injury, whereas axons in the central nervous system (CNS) lack this ability. This difference makes recovery after CNS injury extremely challenging, especi...

Academic Background The field of neuroscience has long been dedicated to understanding how neural circuits generate and control complex behaviors. Although simple model organisms, such as mollusks, crustaceans, and annelids, have provided valuable models for research due to their accessible nervous systems and large characteristic neurons, in many ...

S-nitrosylation of CRTC1 in Alzheimer’s Disease Impairs CREB-dependent Gene Expression Induced by Neuronal Activity Academic Background Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by the gradual loss of memory and cognitive function. The pathological mechanisms of AD are complex, involving various molecular and cel...

Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...