Photocrosslinkable Human Amniotic Membrane Hydrogel for Recovery from Spinal Cord Injury

Photocrosslinked Human Amniotic Membrane Hydrogel for Spinal Cord Injury Repair Academic Background Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to loss of motor function and a decline in the quality of life for patients. Despite significant advancements in tissue engineering and regenerative medicine in recent years,...

3D Bioprinting of Tumor Models and Potential Applications

3D Bioprinting of Tumor Models and Their Potential Applications: A Review Academic Background Cancer is one of the leading causes of human mortality worldwide. Its uncontrolled abnormal proliferation, rapid growth, metastasis, and high heterogeneity result in extremely low clinical translation rates for traditional two-dimensional (2D) cell culture...

Electrospun Polyvinyl Alcohol Fibres Incorporating an Antimicrobial Gel for Enzymatically Controlled Reactive Oxygen Species Release

Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...

3D-Bioprinted Tri-Layered Cellulose/Collagen-Based Drug-Eluting Fillers for the Treatment of Deep Tunneling Wounds

3D Bioprinted Cellulose/Collagen-Based Drug-Eluting Fillers for the Treatment of Deep Tunneling Wounds Academic Background Deep tunneling wounds are complex injuries that form beneath the skin surface, varying in shape and size, and may have twists and turns, making treatment extremely challenging. Current wound care solutions primarily target supe...

Light/pH Dual Controlled Drug Release 'Nanocontainer' Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy

Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...

Temporal and Spatial Regulation of Biomimetic Vascularization in 3D-Printed Skeletal Muscles

Temporal and Spatial Regulation of Biomimetic Vascularization in 3D-Printed Skeletal Muscles

Application of 3D Printing Technology in Skeletal Muscle Vascularization Research Academic Background Skeletal muscle tissue is one of the most important tissues in the human body, and its function relies on the close relationship between myotubes and the vascular network. The vascular network not only supplies oxygen and nutrients to skeletal musc...

Crystalloid Volume Versus Catecholamines for Management of Hemorrhagic Shock During Esophagectomy: Assessment of Microcirculatory Tissue Oxygenation of the Gastric Conduit in a Porcine Model Using Hyperspectral Imaging

Study on Crystalloid Volume versus Catecholamine Strategies for Managing Hemorrhagic Shock during Esophagectomy Academic Background Esophageal cancer is a common malignant tumor worldwide, and surgical resection is one of the primary treatment methods. However, esophagectomy is a complex procedure involving two body cavities (thoracic and abdominal...

Treatment Patterns and Prognosis of Patients with Clear Cell Adenocarcinoma of the Cervix: A Population-Based Cohort Study

Treatment Patterns and Prognosis of Clear Cell Adenocarcinoma of the Cervix: A Research Study Academic Background Cervical cancer ranks as the fourth most common gynecological malignancy globally and the third leading cause of cancer-related mortality in women. Among its subtypes, clear cell adenocarcinoma of the cervix (CCAC) is an extremely rare ...

Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Utilizing Bifurcated Allogeneic Vein Grafts: A Novel Approach for Preventing Sinistral Portal Hypertension Following Pancreaticoduodenectomy. A 10-Year Before and After Study

Utilizing Bifurcated Allogeneic Vein Grafts to Prevent Sinistral Portal Hypertension Following Pancreaticoduodenectomy Academic Background Pancreatic cancer is a highly malignant tumor with a poor prognosis, with a 5-year survival rate of less than 10%. The early invasive growth of pancreatic cancer often involves the portal vein system, particular...