Regularly Updated Benchmark Sets for Statistically Correct Evaluations of AlphaFold Applications

Academic Background: Crossing into a New Era of Protein Structure Prediction Protein structure determination has long stood as one of the central challenges in molecular biology and life sciences. Traditional experimental methods such as X-ray crystallography, nuclear magnetic resonance (NMR), and cryo-electron microscopy have provided a solid foun...

Consensus Statement on the Credibility Assessment of Machine Learning Predictors

1. Background: Machine Learning in Medicine and the Challenge of Credibility In recent years, the rapid development of Artificial Intelligence (AI) and Machine Learning (ML) technologies has brought about a tremendous transformation in the field of healthcare. Particularly in in silico medicine, machine learning predictors have become vital tools f...

Enhancing Multi-Resonance Thermally Activated Delayed Fluorescence Emission via Through-Space Heavy-Atom Effect

Academic Background Organic light-emitting diode (OLED) technology has made remarkable progress in recent years, especially in the field of thermally activated delayed fluorescence (TADF) materials. TADF materials achieve high-efficiency emission by converting triplet excitons into singlet excitons through the reverse intersystem crossing (RISC) pr...

Beyond Natural Synthesis via Solar-Decoupled Biohybrid Photosynthetic System

Beyond Natural Synthesis via Solar-Decoupled Biohybrid Photosynthetic System

Academic Background Photosynthetic microorganisms can directly convert carbon dioxide (CO₂) into high value-added long-chain chemicals by converting solar energy into chemical energy, providing a promising route for CO₂ sequestration and sustainable development. However, the key reducing power generated in photosynthetic reactions—nicotinamide aden...

Borohydride Oxidation-Water Reduction Fuel Cells Advanced by Local Hydroxyl Enrichment-Inhibited Borohydride Hydrolysis on Cu(0) Sites

Academic Background Direct Borohydride Fuel Cells (DBFCs), as a potential carbon-neutral energy source, have attracted considerable attention due to their use of sodium borohydride (NaBH4) as the anode fuel. NaBH4 possesses advantages such as portability, non-toxicity, water solubility, and environmental stability, allowing DBFCs in theory to deliv...

Antigen Spatial-Matching Polyaptamer Nanostructure to Block Coronavirus Infection and Alleviate Inflammation

Academic Background In recent years, multiple outbreaks caused by coronaviruses have occurred globally, such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), and COVID-19 (Novel Coronavirus Pneumonia). These pandemics have not only posed a serious threat to human health but also exposed the inadequacy of emergen...

Drinking Water Purification Using Metal-Organic Frameworks: Removal of Disinfection By-Products

Academic Background With the increasing severity of global clean water shortages, research on drinking water purification technologies has become particularly important. In drinking water treatment processes, chlorination and chlorine dioxide disinfection are commonly used methods. Although they effectively kill bacteria and viruses, they also prod...

Cluster-Based Redox-Responsive Super-Atomic MRI Contrast Agents

Academic Background Magnetic Resonance Imaging (MRI) is a crucial tool in modern medical diagnostics, and its effectiveness relies heavily on the use of contrast agents (CAs). Traditional MRI contrast agents are mainly based on gadolinium (Gd) complexes. Although these agents are widely used in clinical practice, their long-term safety is controver...

Binolates as Potent Reducing Photocatalysts for Inert-Bond Activation and Reduction of Unsaturated Systems

Academic Background In the field of photocatalysis, the development of efficient and sustainable reducing catalysts has long been a significant research focus. Organic anions have attracted considerable attention in recent years due to their sustainability and strong reducing abilities. However, traditional phenolates are limited in their applicati...

Amorphous CuSBox Composite-Catalyzed Electrocatalytic Reduction of CO2 to CO: CO2 Demand-Supply-Regulated Performance

Academic Background As the issue of global climate change intensifies, reducing carbon dioxide (CO2) emissions and seeking sustainable energy solutions have become major directions in scientific research. Electrocatalytic CO2 reduction (CO2RR) is a green technology that converts CO2 into value-added chemicals and fuels, holding enormous application...