Early Detection of Uveal Melanoma Using Electrical Impedance Spectroscopy Academic Background Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high aggressiveness, which can lead to vision loss and even life-threatening outcomes. Early detection and timely treatment are crucial for preserving vision ...

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

Experience-Dependent Dopamine Modulation of Male Aggression in Mice Academic Background Aggression is a common social behavior in the animal kingdom, crucial for territory defense, resource competition, and mate protection. Although the role of dopamine in regulating aggression has been extensively studied, its specific neural mechanisms remain unc...

Genomic Research on Bipolar Disorder Background Introduction Bipolar Disorder (BD) is a severe mental illness that significantly contributes to the global disease burden. Despite its high heritability (60-80%), the majority of its genetic basis remains unclear. Previous studies have primarily focused on European populations, with limited exploratio...

Extended Quantum Anomalous Hall States in Graphene/Hexagonal Boron Nitride Moiré Superlattices Academic Background In recent years, the behavior of electrons in topological flat bands has attracted widespread attention in the field of condensed matter physics. Electrons in topological flat bands can form new topological states driven by strong corr...

Spatiotemporal Imprinting of Tissue-Resident Memory CD8 T Cell Diversity Background Tissue-resident memory CD8 T cells (TRM cells) provide long-term immune protection at barrier sites such as the intestine. However, the heterogeneity of TRM cells and the mechanisms underlying their formation remain incompletely understood. Previous studies have ide...

Background Introduction In recent years, the discovery of superconductivity in twisted bilayer and trilayer graphene has sparked widespread interest. The key feature of these systems lies in the interplay between interlayer coupling and moiré superlattices, which gives rise to low-energy flat bands with strong correlations. Similar flat bands can a...

Study on Chorus Waves and Field-Particle Energy Transfer in Space Academic Background Chorus waves are among the strongest naturally occurring electromagnetic emissions, widely observed in the magnetospheres of Earth and other planets. These waves not only pose radiation hazards to satellites and astronauts but also play a crucial role in accelerat...

Global 3D Model of Mantle Attenuation: A Study Based on Seismic Normal Modes Academic Background The structure and dynamic processes of Earth’s interior have always been at the core of geoscientific research. Mantle convection is the primary mechanism driving plate tectonics, volcanic eruptions, and earthquakes. However, traditional seismic tomogra...

The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...