Volumetric Additive Manufacturing for Cell Printing: Bridging Industry Adaptation and Regulatory Frontiers

Applications of Volumetric Additive Manufacturing in Cell Printing Academic Background Volumetric Additive Manufacturing (VAM) is a revolutionary 3D printing technology capable of rapidly creating complex three-dimensional structures, particularly in the field of cell printing. VAM can mimic the structures of natural tissues, offering new possibili...

Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration

Advanced Bioresponsive Drug Delivery Systems for Diabetic Vascularized Bone Regeneration Background The treatment of bone defects in patients with Diabetes Mellitus (DM) remains a significant challenge, as the diabetic microenvironment severely impedes bone regeneration. Various abnormal factors in the diabetic microenvironment, such as hyperglycem...

Self-Assembled DNA−Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation

Self-Assembled DNA-Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation Academic Background In molecular biology research, the interaction between DNA and proteins has always been a crucial topic for understanding cellular processes. With the deepening understanding of DNA-protein interactions, this knowledge has been w...

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...

Synthesis of Palladium Nanoparticles by Electrode-Respiring Geobacter sulfurreducens Biofilms

Synthesis of Palladium Nanoparticles by Electrode-Respiring Geobacter sulfurreducens Biofilms Research Background In modern industry and environmental science, palladium (Pd) serves as a crucial catalyst widely used in pharmaceuticals, agriculture, and chemical industries. However, traditional methods for synthesizing palladium nanoparticles (Pd NP...

Assembly of Recombinant Proteins into β-Sheet Fibrillating Peptide-Driven Supramolecular Hydrogels for Enhanced Diabetic Wound Healing

Supramolecular Hydrogels Driven by β-Sheet Fibrillating Peptides for Enhanced Diabetic Wound Healing Academic Background Diabetic wound healing is a global health issue. Due to microvascular complications and immune dysfunction caused by hyperglycemia, the wound healing process in diabetic patients is often severely hindered. Traditional treatments...

Early Pleistocene Glacier Ice Preserved in Permafrost in the Eastern Canadian Arctic

Early Pleistocene Glacier Ice Preserved in Permafrost in the Eastern Canadian Arctic Academic Background Permafrost is a crucial paleoenvironmental archive on Earth, capable of preserving valuable information such as fossils, plant remains, organic materials, and ancient DNA. In recent years, scientists have discovered that the preservation of glac...

Marsh Topography Reveals the Signature of Storm-Surge-Driven Sedimentation

Salt Marsh Topography Reveals the Signature of Storm-Surge-Driven Sedimentation Academic Background Salt marshes are transitional zones located in low-lying, sheltered coastlines, situated between land and sea. They are among the most productive and fragile ecosystems on Earth, providing essential ecological services such as carbon sequestration, w...

Diachronous End-Permian Terrestrial Crises in North and South China

Terrestrial Ecosystem Crisis at the Permian-Triassic Boundary Academic Background The Permian-Triassic boundary (approximately 252 million years ago) marks one of the most severe mass extinction events in Earth’s history, devastating not only marine ecosystems but also profoundly impacting terrestrial ecosystems. Although scientists generally agree...