Communication Between Cancer Cell Subtypes by Exosomes Contributes to Nasopharyngeal Carcinoma Metastasis and Poor Prognosis

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining of the nasopharynx, characterized by a distinct geographical distribution, particularly with high incidence rates in Southeast Asia and Southern China. Despite significant progress in NPC treatment in recent years, the prognosis for patients remains poor, esp...

Deep Learning-Based Multi-Modal Data Integration Enhancing Breast Cancer Disease-Free Survival Prediction

Breast cancer is one of the most common malignancies among women worldwide. Although early intervention and appropriate treatment have significantly improved patient survival rates, approximately 30% of cases still experience recurrence and distant metastasis, resulting in a 5-year survival rate of less than 23%. Traditional clinical prediction met...

Suppression of Myd88 Disturbs Gut Microbiota and Activates the NLR Pathway and Hence Fails to Ameliorate DSS-Induced Colitis

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, primarily including Ulcerative Colitis (UC) and Crohn’s Disease (CD). In recent years, the incidence of IBD has been on the rise globally, placing a significant burden on healthcare systems. Although it is widely accepted that IBD is associ...

Depletion of Squalene Epoxidase in Synergy with Glutathione Peroxidase 4 Inhibitor RSL3 Overcomes Oxidative Stress Resistance in Lung Squamous Cell Carcinoma

Lung cancer is one of the leading causes of death worldwide, with lung squamous cell carcinoma (LUSC) being a subtype of non-small cell lung cancer (NSCLC), accounting for 20%-30% of all NSCLC cases. Despite significant advancements in lung cancer treatment in recent years, LUSC still lacks effective targeted therapies, and patients have a poor pro...

Phenotypic Age Mediates Effects of Life’s Essential 8 on Reduced Mortality Risk in US Adults

Aging is one of the major risk factors for a variety of chronic diseases and death. However, chronological age does not fully reflect individual differences in the biological aging process. Phenotypic age is a composite score based on routine clinical markers, used to differentiate individuals within the same age group who have varying risks of dis...

International Multicentre Validation of the Left Pancreatectomy Pancreatic Fistula Prediction Models and Development and Validation of the Combined DISPAIR-FRS Prediction Model

Academic Background Pancreatectomy is an important treatment for pancreatic diseases, but postoperative pancreatic fistula (POPF) is a common and serious complication, with an incidence rate as high as 20%. POPF not only prolongs hospital stays and increases medical costs but is also closely associated with increased postoperative mortality. Theref...

Impact of PD1 Blockade Added to Neoadjuvant Chemoradiotherapy on Rectal Cancer Surgery: Post-Hoc Analysis of the Randomized POLARSTAR Trial

Background Colorectal cancer is the third most common cancer type globally, with the greatest disease burden in East Asia. In China, 47% of newly diagnosed colorectal cancers are rectal cancers, of which 70% are radiologically staged as locally advanced (stage II/III) at diagnosis. For decades, neoadjuvant chemoradiotherapy (CRT) combined with tota...

Impact of Postoperative Complications on Clinical Outcomes After Gastrectomy for Cancer: Multicentre Study

Gastric cancer is one of the most common malignant tumors worldwide, and surgical resection (gastrectomy) is the primary treatment. Although the application of minimally invasive techniques has reduced surgical trauma, the incidence of postoperative complications after gastrectomy remains high, ranging from 20% to 40%. These complications not only ...

Development and External Validation of Prediction Risk Scores (StrISK and NOFA) to Predict Immediate Surgical Need in Adhesive Small Bowel Obstruction: An Observational Prospective Multicentre Study

Background Introduction Adhesive Small Bowel Obstruction (ASBO) is one of the leading causes of emergency admissions, accounting for approximately 60% of all small bowel obstruction cases. ASBO is often caused by postoperative intra-abdominal adhesions, with patients presenting symptoms such as abdominal pain, vomiting, and constipation. While most...

Routine Anaesthesia Ward-Based Patient Visits in Surgery: 1-Year Outcomes of the TRACE Randomized Clinical Trial

In perioperative medicine, the long-term clinical and functional recovery of postoperative patients has always been a focus of research. Traditionally, postoperative complications, mortality, readmission rates, and reoperation rates have been the primary indicators for measuring surgical patient outcomes. However, as medical research deepens, an in...