Patient-Derived Acellular Ascites Fluid Affects Drug Responses in Ovarian Cancer Cell Lines Through the Activation of Key Signalling Pathways

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Immunology,
ovarian cancer   acellular ascites fluid   drug sensitivity   signalling pathways   chemoresistance  

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...

APOBEC3C-mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression

Medicine, Nephrology, Oncology, Life Sciences, Biochemistry, Immunology,
Clear cell renal cell carcinoma   APOBEC3C   NF-κB   RNA-binding protein   Tumor progression  

APOBEC3C-Mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression Academic Background Clear cell renal cell carcinoma (CCRCC) is the most common subtype of kidney cancer, accounting for approximately 75% of all kidney cancer cases. Although immunotherapy has shown some potential in treating CCRCC, the treatment of metastatic C...

WWP1 Regulates TXNIP Ubiquitination and Degradation in Acute Myeloid Leukemia Cells via Redox State Modulation

Medicine, Hematology, Oncology, Life Sciences, Biochemistry,
acute myeloid leukemia   ubiquitination   redox homeostasis   reactive oxygen species   WWP1   TXNIP   apoptosis  

WWP1 Regulates Redox State in Acute Myeloid Leukemia Cells by Modulating TXNIP Background Acute myeloid leukemia (AML) is a malignant blood disorder characterized by the abnormal proliferation of immature leukemia cells (leukemic blasts) in the bone marrow. Although significant progress has been made in the treatment of AML in recent years, the lon...

A Two-Phase Epigenome-Wide Four-Way Gene–Smoking Interaction Study of Overall Survival for Early-Stage Non-Small Cell Lung Cancer

Medicine, Respiratory System, Oncology,
epigenomics   four-way interaction   gene–smoking interaction   non-small cell lung cancer   survival analysis   DNA methylation   molecular mechanisms  

Study on the Four-Way Gene-Smoking Interaction and Survival in Early-Stage Non-Small Cell Lung Cancer Research Background Lung cancer is one of the most prevalent malignancies worldwide and a leading cause of cancer-related mortality. According to global cancer statistics, approximately 2.5 million new cases are diagnosed annually, with 1.8 million...

Enhancing Immunotherapy Through PD-L1 Upregulation: The Promising Combination of Anti-PD-L1 Plus mTOR Inhibitors

Medicine, Urology, Oncology, Life Sciences, Immunology,
bladder cancer   PD-L1   mTOR inhibitors   immune checkpoint inhibitors   tumor microenvironment  

Enhancing Immunotherapy Potential Through PD-L1 Upregulation—Combination of Anti-PD-L1 and mTOR Inhibitors Background Introduction In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in cancer treatment, particularly in the treatment of urothelial cancer (UC). PD-1/PD-L1 inhibitors restore T cell anti-tumor activity ...

Simultaneous Detection of Eight Cancer Types Using a Multiplex Droplet Digital PCR Assay

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
cancer detection   DNA methylation   droplet digital PCR   multiplexing   biomarkers   early diagnosis   tumor prediction  

Multi-Cancer Detection Using Multiplex Droplet Digital PCR Methylation Assay Background Cancer is one of the leading causes of death worldwide, with nearly 10 million deaths reported in 2020. Although many cancers can be cured when detected and treated early, many patients are still diagnosed at advanced stages, leading to poor treatment outcomes. ...

Dynamic Methylation and Expression of Alternative Promoters for Oestrogen Receptor Alpha in Cell Line Models of Fulvestrant Resistance

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
breast cancer   drug resistance   fulvestrant   methylation   oestrogen receptor   promoter  

Dynamic Changes in Estrogen Receptor Alpha (ERα) Promoter Methylation and Drug Resistance in Breast Cancer Cells Background Breast cancer is one of the most common cancers among women worldwide, with approximately 75% of breast cancer patients expressing estrogen receptor alpha (ERα, gene symbol ESR1). ERα is not only an important prognostic marker...

Assessments of Prostate Cancer Cell Functions Highlight Differences Between a Pan-PI3K/mTOR Inhibitor, Gedatolisib, and Single-Node Inhibitors of the PI3K/AKT/mTOR Pathway

Medicine, Urology, Oncology,
prostate cancer   PI3K/AKT/mTOR pathway   Gedatolisib   single-node inhibitors   cell functions  

Prostate Cancer Cell Function Assessments Reveal Differences Between Gedatolisib and Single-Node PI3K/AKT/mTOR Inhibitors Academic Background Prostate cancer (PC) is one of the most common cancers among men worldwide, particularly in advanced stages where patients often develop resistance to androgen deprivation therapy (ADT), progressing to castra...

The Genetic Duet of Concurrent RASAL1 and PTEN Alterations Promotes Cancer Aggressiveness by Cooperatively Activating the PI3K–AKT Pathway

Medicine, Endocrinology, Oncology,
cancer aggressiveness   PI3K pathway   PTEN   RASAL1   tumor suppressor gene  

Mechanism of RASAL1 and PTEN Co-Alterations Promoting Cancer Aggressiveness Academic Background Cancer is one of the leading causes of death worldwide, and its occurrence and progression involve abnormalities in multiple genes and signaling pathways. The PI3K-AKT signaling pathway plays a crucial role in cancer, and its overactivation is closely re...

IDH Mutation, Glioma Immunogenicity, and Therapeutic Challenge of Primary Mismatch Repair Deficient IDH-Mutant Astrocytoma (PMMRDIA): A Systematic Review

Medicine, Neurosurgery, Oncology, Life Sciences, Immunology,
IDH mutation   glioma   immunogenicity   mismatch repair deficiency   astrocytoma   therapeutic challenge   systematic review  

Immunogenicity and Therapeutic Challenges of IDH-Mutant Gliomas Background Glioma is a common central nervous system tumor, and its treatment and prognosis vary significantly depending on molecular characteristics. In recent years, the diagnostic and prognostic significance of isocitrate dehydrogenase (IDH) mutations in gliomas has been increasingl...