Short-term Cold Exposure Induces Persistent Epigenomic Memory in Brown Adipose Tissue Background Brown Adipose Tissue (BAT) is the primary non-shivering thermogenic organ in mammals that dissipates chemical energy as heat under cold stimuli. BAT is characterized by a high density of mitochondria containing Uncoupling Protein 1 (UCP1), which generat...

Intermittent Clearance of High p21-Expressing Cells Extends Lifespan and Delivers Sustained Health Benefits Research Background With the significant extension of human lifespan, the global elderly population is rapidly increasing. Elderly individuals often face decreased functionality and various chronic diseases in their later years, such as cardi...

Macroscopic and Microscopic Mechanisms of Nicotinamide Metabolism Antagonism: Manipulation of the Gastric Cancer Microenvironment Background Introduction Gastric cancer (GC) is a type of cancer characterized by a unique and heterogeneous tumor microenvironment (TME). Despite advances in immune checkpoint blockade (ICB) therapy for gastric cancer, n...

A Microbial Metabolite Mediates the Beneficial Effects of Time-Restricted Feeding on MASH by Inhibiting the HIF-2A-Ceramide Pathway Introduction Background: Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH) is a major health problem affecting a quarter of the global population. MA...

Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...

Inhibition of the electron transport chain increases cell dependence on purine transport and salvage Research Background The electron transport chain (ETC) is a key mechanism in mitochondria responsible for energy generation, playing an important role in maintaining cellular homeostasis and growth. However, it remains unclear how cells adjust their...

Diabetic Retinopathy as a Ceramide Disease Reversible by Anti-Ceramide Immunotherapy Background Diabetic Retinopathy (DR) is one of the most common metabolic disorders worldwide. Diabetes not only leads to chronic complications in macrovascular and microvascular systems but also imposes significant socio-economic burdens. As a microvascular complic...

Study Reveals Tirzepatide Regulates Adipocyte Nutritional Metabolism Through Long-Acting Activation of GIP Receptor Academic Background With global chronic nutritional excess and lack of exercise, obesity and type 2 diabetes (T2D) and their related complications (such as cardiovascular diseases) have reached epidemic levels. These conditions not on...

Obesity Disrupts Pituitary-Hepatic UPR Communication Leading to NAFLD Progression Background and Research Objectives In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly. Research suggests that obesity, a major risk factor for NAFLD, disrupts hepatic immunometabolic homeostasis by affecting systemi...

A Human Omentum-Specific Intermesothelial Fibroblast Population Inhibits Adipogenesis by Secreting IGFBP2 Background and Research Objective With the growing prevalence of obesity and metabolic diseases, the plasticity and heterogeneity of adipose tissue have become research hotspots. Different regions of adipose tissue exhibit distinct metabolic ch...