Novobiocin Primarily Targets ParE in Neisseria gonorrhoeae Background Neisseria gonorrhoeae is a Gram-negative bacterium that causes gonorrhea, one of the most common sexually transmitted infections worldwide. According to the World Health Organization (WHO), there were 82.3 million new cases of gonorrhea among people aged 15–49 in 2020. However, t...

Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...

Discovery of Celludinone C and Its SOAT Inhibitory Activity Academic Background Sterol O-Acyltransferase (SOAT) is an enzyme that catalyzes the esterification of cholesterol and plays a critical role in maintaining intracellular lipid homeostasis. SOAT has two isozymes, SOAT1 and SOAT2, which exhibit significant differences in tissue distribution a...

Identification of Nanaomycin A and Its Analogs as Functional Inhibitors of the Type IX Secretion System in Porphyromonas gingivalis Using a Novel Screening Method Academic Background Porphyromonas gingivalis is a Gram-negative anaerobic bacterium recognized as one of the primary pathogens in chronic periodontitis. Beyond periodontal diseases, P. gi...

Discovery and Research of the New Antibiotic Thiazoplanomicin Academic Background In recent years, the issue of antibiotic resistance has become increasingly severe, particularly with Neisseria gonorrhoeae (gonococcus), a common sexually transmitted pathogen. Gonococcus can rapidly develop drug resistance, rendering traditional antibiotics such as ...

Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance Academic Background Milbemycins are a class of 16-membered macrolides produced by Streptomyces, exhibiting potent anthelmintic and insecticidal activities with low mammalian toxicity. Milbemycins and their derivatives are widely used in agriculture and ve...

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Structure-Activity Relationship Studies of ME1111—A Novel Antifungal Agent for Topical Treatment of Onychomycosis Background Onychomycosis is a globally prevalent disease affecting approximately 5.5% of the world’s population. Among its subtypes, distal-lateral subungual onychomycosis (DLSO) is the most common. The treatment of onychomycosis typica...

ctDNA Trajectories Predict Survival in Trifluridine/Tipiracil-Treated Metastatic Colorectal Cancer Patients Academic Background Metastatic colorectal cancer (mCRC) is one of the leading causes of cancer-related deaths worldwide. Despite recent advancements in diagnosis and treatment, the prognosis for advanced-stage patients remains poor. Triflurid...

Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...