Epithelial−Mesenchymal Transition Induced by Tumor Cell-Intrinsic PD-L1 Signaling Predicts a Poor Response to Immune Checkpoint Inhibitors in PD-L1-High Lung Cancer

Tumor Cell-Intrinsic PD-L1 Signaling Induces Epithelial-Mesenchymal Transition (EMT) Predicting Poor Response to Immune Checkpoint Inhibitors in PD-L1 High-Expressing Lung Cancer Research Background and Motivation In cancer immunotherapy, Programmed Death Ligand-1 (PD-L1) inhibits immune responses by binding to Programmed Death-1 (PD-1) receptors o...

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

Achieving Synergistic Antitumor Activity by Dual Blocking of CCR1 and CXCR2 Expression in Myeloid Cells Background Introduction Colorectal Cancer (CRC) poses a global health crisis, with its incidence and mortality rates rapidly rising in recent years. Over the past 15 years, the mortality rate of CRC has increased by more than 30%, and it is expec...

Hypoxia- and Postirradiation Reoxygenation-Induced HMHA1/ARHGAP45 Expression Contributes to Cancer Cell Invasion in a HIF-Dependent Manner

Contribution of HMHA1/ARHGAP45 Expression Induced by Hypoxia and Post-Radiation Reoxygenation to Cancer Cell Invasion: An HIF-Dependent Mechanism Background and Motivation Prior studies have extensively demonstrated that cancer cells in solid tumors acquire malignant characteristics such as invasiveness and treatment resistance under hypoxic condit...

Genomic Profiling of Small Bowel Adenocarcinoma: A Pooled Analysis from 3 Databases

Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...

Oncofetal SNRPE Promotes HCC Tumorigenesis by Regulating FGFR4 Expression through Alternative Splicing

Study on the Key Role of Oncofetal snrpe in the Tumorigenesis and Progression of Hepatocellular Carcinoma Research Background and Purpose Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. However, due to the lack of understanding of key molecular events in tumors, effec...

Tumour Microenvironment-Mediated Drug Resistance in Neuroblastoma

Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...

Effects of a Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Patients with Ovarian Cancer: Results of the Padova Trial

Effects of a Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Patients with Ovarian Cancer: Results of the Padova Trial

Effects of Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Ovarian Cancer Patients: PADOVA Trial Results Academic Background Ovarian cancer is the seventh most common cancer among women, usually detected at an advanced stage, with an overall 5-year survival rate as low as 30-40%. Standard ovarian...

Plasma Membrane Damage Limits Replicative Lifespan in Yeast and Induces Premature Senescence in Human Fibroblasts

Scientific Research Report: Plasma Membrane Damage Limits Yeast Replicative Lifespan and Induces Premature Senescence in Human Fibroblasts Background and Research Motivation Plasma Membrane Damage (PMD) is a phenomenon experienced by all cell types in response to environmental disturbances and spontaneous cellular activities. Previous studies have ...

HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...

Efficacy-Effectiveness Analysis on Survival in a Population-Based Real-World Study of BRAF-Mutated Metastatic Colorectal Cancer Patients Treated with Encorafenib-Cetuximab

Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...