The research results, completed in collaboration by many scientists including Lishu Chen, Qinghui Qi, and Xiaoqing Jiang, were published in the groundbreaking journal Cancer Discovery. The report detailed how phosphocreatine (PCr) promotes the growth of glioblastoma (GBM) by stabilizing bromodomain-containing protein 2 (BRD2). This discovery provid...
Research Report on the Regulation of Neuron-Glioma Interactions by CHD2 in Pediatric Gliomas Background High-grade gliomas (HGG) are fatal diseases in both adult and pediatric patients. Recent studies have shown that neuronal activity can promote the progression of various high-grade glioma subgroups. However, the epigenetic mechanisms regulating t...
Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...
Cerebrospinal Fluid Proteomics Study for Diagnosis and Prediction of Alzheimer’s Disease Background and Research Objectives Alzheimer’s disease (AD) is a neurodegenerative disease that leads to memory loss and cognitive decline, and currently, there is no effective cure globally. Traditionally, the pathological features of AD include β-amyloid (Aβ)...
Study on the Genetic and Environmental Effects of Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence I. Background and Significance Adverse childhood events (ACE) often have profound effects on an individual’s mental health and substance dependence. Previous studies have shown a close relationship between ACE and mood an...
Decision Uncertainty as a Contextual Cue for Motor Memory Background In a penalty shootout during a soccer match, players may face two distinctly different decision-making scenarios. For example, a player may decisively kick the ball to the right corner after seeing the goalkeeper move to the other side, or he may kick the same way without being ce...
The Necessity of the Human Ventromedial Prefrontal Cortex for Prosocial Motivation Research Background and Motivation The ventromedial prefrontal cortex (vmPFC) plays a crucial role in decision-making processes. Functional neuroimaging studies indicate that the vmPFC is key in handling rewards and efforts and is also associated with prosocial behav...
Functional Connectivity Across the Brain and Temporally Enhanced Non-neuronal Low-Frequency Oscillation (SLFO) Blood Flow Signal Based on Functional Magnetic Resonance Imaging Scans In the field of neuroscience, a core question is how the brain’s connectivity reconfigures over time to support adaptive functional changes. These dynamically changing ...
Academic Background RNA isoforms play a critical role in gene expression regulation. On average, human protein-coding genes contain over eight RNA isoforms, leading to nearly four distinct protein-coding sequences. Traditional short-read sequencing technologies, due to their limitations in read length, cannot accurately assemble and quantify RNA is...
Central Nervous System (CNS) autoimmune diseases, such as Neuromyelitis Optica Spectrum Disorders (NMOSD), are inflammatory demyelinating conditions characterized by relapses of optic neuritis and myelitis. Despite significant progress in the treatment of NMOSD, a subset of patients responds poorly to current therapies, with recurrent and difficult...