Study on the Role of Machine Learning-Assisted Quantitative Hyperspectral Imaging in Brain Tumor Resection Background Introduction Complete resection of malignant gliomas has always been challenged by the difficulty of distinguishing tumor cells in invasive regions. The background of this study is: In neurosurgery, the application of 5-aminolevulin...

The Mediating Role of Systemic Inflammation in the Differences in Cognitive Disease Incidence and the Moderating Role of Racialization This study examines the link between systemic racism and the increased burden of cognitive disease. Researchers investigated the mediating role of C-reactive protein (CRP) as a marker of systemic inflammation in the...

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...

Research Report: Ternary Analysis of Mediterranean Diet, Gut Microbiota, and Juvenile Onset Multiple Sclerosis Research Background Multiple Sclerosis (MS) is an autoimmune disease in which the immune system attacks the protective layer of nerve cells. Numerous studies have indicated that environmental risk factors, such as low vitamin D levels and ...

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...

Scientific Research Report Background Introduction For a long time, aging has been considered an irreversible process. However, recent research suggests that aging is a biological process that can be regulated. Various interventions have been shown to delay or even reverse certain characteristics of aging. Partial reprogramming is a method that rev...

In the global context, the Planetary Health Diet has been proposed as a way to improve human health while protecting the Earth. However, studies on the relationship between the Planetary Health Diet and cognitive decline are very limited. To fill this research gap, researchers Natalia Gomes Gonçalves, Leandro Teixeira Cacau, Naomi Vidal Ferreira, P...

Improvement of Cognitive Impairment Induced by Hearing Loss Background Alzheimer’s Disease (AD) is a common dementia characterized by extracellular amyloid plaques formed by aggregation of amyloid-β (Aβ) and intracellular neurofibrillary tangles formed by aggregated tau protein. Epidemiological studies indicate a close correlation between hearing l...

Research Background and Objectives With over 50 million people worldwide affected by cognitive impairment disorders, this number is expected to double by 2050. Alzheimer’s disease (AD) is the most common form of dementia, characterized by extracellular amyloid-beta (Aβ) plaques and intracellular tau protein aggregates in the brain. Over the past tw...

Plasma Proteomics Predicts the Future Risk of Dementia in Healthy Adults Background and Significance Predicting dementia has always been a significant challenge in the medical field. With the development of proteomics, biomarkers in the blood offer new opportunities for predicting the onset of dementia. This study focuses on data from the UK Bioban...