Scientific News Report: The Molecular and Neural Circuit Mechanisms in the Globus Pallidus for Controlling Cocaine-Induced Behavioral Plasticity In the field of the neurobiology of drug abuse, this paper provides a new perspective for exploring cocaine-induced behavioral plasticity and neural circuit regulation. The research team centered on the Gl...
I. Research Background The taste of food has a significant impact on the feeding motivation of animals. Previous research has shown that taste, as a positive feedback signal, can enhance the feeding motivation of animals. However, in recent years, studies on whether taste also plays a role in suppressing feeding and helping achieve negative feedbac...
Research Background The neural transduction mechanisms of tactile vibration coding have been a hot topic in neuroscience research. In daily life, we acquire information about the external environment through the perception of vibrations, such as phone vibration alerts or car proximity warnings. In mammals, high-frequency vibration perception is mai...
With the advancement of neuroscience research, the crucial role of N-methyl-D-aspartate receptors (NMDA receptors, NMDAR) in neurotransmission and cognitive functions has become increasingly clear. NMDARs are a type of ionotropic glutamate receptor that play an important role in neuronal synapses, responsible for rapid excitatory transmission and s...
Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...
In a study titled “Visual Experience Reduces the Spatial Redundancy between Cortical Feedback Inputs and Primary Visual Cortex Neurons,” Rodrigo F. Dias, Radhika Rajan, and their team explored how visual experience influences the spatial redundancy of cortical feedback pathways. This research was carried out by scientists from the Champalimaud Neur...
Reversible Regulation of Retinal and Peripheral Nerve Function: Physiological Study of Serine and Glycine Background and Research Motivation Macular Telangiectasia Type 2 (Mactel) is an age-related retinal disease characterized by central vision loss. The molecular etiology of this disease is complex and is primarily associated with the metabolism ...
Obesity Aggravates Female Central Nervous System Autoimmune Diseases Through Sex-Specific Interferon Signaling In recent years, the rising incidence of central nervous system (CNS) autoimmune diseases in females has garnered widespread attention. Obesity, as a potential environmental risk factor, has gradually become a research hotspot. The latest ...
Integration of Electrophysiological and Genomic Analysis Reveals Tumor Cells Capable of Generating Action Potentials in Human Gliomas Background and Research Objectives Gliomas are the most common malignant tumors in the central nervous system, with approximately 20,000 new cases annually. These tumors include two subtypes: isocitrate dehydrogenase...
Fibrotic Response Induced by Anti-CSF-1R Treatment Promotes Glioblastoma Recurrence Background Introduction Glioblastoma (GBM) is a highly aggressive and malignant primary tumor of the central nervous system. Although current standard treatments include surgical resection, Temozolomide chemotherapy, and fractionated radiotherapy, the median surviva...