Cerebral amyloid angiopathy (CAA) is a disease caused by the deposition of amyloid-beta (Aβ) in cerebral blood vessels. It is common not only in the elderly and almost all patients with Alzheimer’s disease (AD) but can also occur independently of other AD-related pathologies. The presence and severity of CAA promote the progression of AD-related cl...

Neurohackademy: Combining Online and Offline Neurological Informatics Education Background Introduction In recent years, human neuroscience has entered an era of big data. Due to initiatives like the Human Connectome Project and the Adolescent Brain Cognitive Development (ABCD) study, scientists have acquired datasets of previously unimaginable sca...

Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...

Study on the Role of Machine Learning-Assisted Quantitative Hyperspectral Imaging in Brain Tumor Resection Background Introduction Complete resection of malignant gliomas has always been challenged by the difficulty of distinguishing tumor cells in invasive regions. The background of this study is: In neurosurgery, the application of 5-aminolevulin...

The Mediating Role of Systemic Inflammation in the Differences in Cognitive Disease Incidence and the Moderating Role of Racialization This study examines the link between systemic racism and the increased burden of cognitive disease. Researchers investigated the mediating role of C-reactive protein (CRP) as a marker of systemic inflammation in the...

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...

Research Report: Ternary Analysis of Mediterranean Diet, Gut Microbiota, and Juvenile Onset Multiple Sclerosis Research Background Multiple Sclerosis (MS) is an autoimmune disease in which the immune system attacks the protective layer of nerve cells. Numerous studies have indicated that environmental risk factors, such as low vitamin D levels and ...

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...

Scientific Research Report Background Introduction For a long time, aging has been considered an irreversible process. However, recent research suggests that aging is a biological process that can be regulated. Various interventions have been shown to delay or even reverse certain characteristics of aging. Partial reprogramming is a method that rev...

In the global context, the Planetary Health Diet has been proposed as a way to improve human health while protecting the Earth. However, studies on the relationship between the Planetary Health Diet and cognitive decline are very limited. To fill this research gap, researchers Natalia Gomes Gonçalves, Leandro Teixeira Cacau, Naomi Vidal Ferreira, P...