Study on the Genetic and Environmental Effects of Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence I. Background and Significance Adverse childhood events (ACE) often have profound effects on an individual’s mental health and substance dependence. Previous studies have shown a close relationship between ACE and mood an...
Decision Uncertainty as a Contextual Cue for Motor Memory Background In a penalty shootout during a soccer match, players may face two distinctly different decision-making scenarios. For example, a player may decisively kick the ball to the right corner after seeing the goalkeeper move to the other side, or he may kick the same way without being ce...
The Necessity of the Human Ventromedial Prefrontal Cortex for Prosocial Motivation Research Background and Motivation The ventromedial prefrontal cortex (vmPFC) plays a crucial role in decision-making processes. Functional neuroimaging studies indicate that the vmPFC is key in handling rewards and efforts and is also associated with prosocial behav...
Functional Connectivity Across the Brain and Temporally Enhanced Non-neuronal Low-Frequency Oscillation (SLFO) Blood Flow Signal Based on Functional Magnetic Resonance Imaging Scans In the field of neuroscience, a core question is how the brain’s connectivity reconfigures over time to support adaptive functional changes. These dynamically changing ...
Academic Background RNA isoforms play a critical role in gene expression regulation. On average, human protein-coding genes contain over eight RNA isoforms, leading to nearly four distinct protein-coding sequences. Traditional short-read sequencing technologies, due to their limitations in read length, cannot accurately assemble and quantify RNA is...
Central Nervous System (CNS) autoimmune diseases, such as Neuromyelitis Optica Spectrum Disorders (NMOSD), are inflammatory demyelinating conditions characterized by relapses of optic neuritis and myelitis. Despite significant progress in the treatment of NMOSD, a subset of patients responds poorly to current therapies, with recurrent and difficult...
Oxidative Phosphorylation Regulates B Cell Effector Cytokines and Promotes Inflammation in Multiple Sclerosis Background Introduction In recent years, the antibody-independent functions of B cells in health and disease have become a research hotspot, particularly their ability to secrete different cytokines that can activate or downregulate local i...
Major Breakthrough in Research for Autoimmune Neuroinflammation Treatment Background Introduction Steroid resistance is a significant challenge in the treatment of many inflammatory diseases, particularly autoimmune neuroinflammation. In these diseases, TH17 cells (T helper 17 cells) are widely regarded as key contributors to steroid resistance; ho...
Academic report: brainlife.io: A decentralized and open-source cloud platform supporting neuroscience research Background and Motivation Neuroscience research is rapidly developing, and the advancement of data standardization, management, and processing tools has made research more rigorous and transparent. However, this also brings about complex d...
Research Report on Multi-sensory Flicker Regulating Extensive Brain Networks and Reducing Interictal Epileptiform Discharges Background Introduction In treating neurological disorders, modulating brain oscillations has great potential. Non-invasive interventions, suitable for everyday use at home, have become the focus of the scientific community, ...