Executive Report on the Study of ccRCC Regulatory Mechanisms Using the SIRCLE Model Background Overview Clear Cell Renal Cell Carcinoma (ccRCC) is the most prevalent form of kidney cancer, accounting for 70% of renal malignancies. The development and progression of ccRCC involve intricate remodeling of the kidney epigenome, transcriptome, proteome,...

Report on the Multi-Omics Study of Lung Cancer Brain Metastases (LC-BMs) Academic Background Lung cancer is one of the most prevalent and deadly cancers worldwide. Lung cancer brain metastases (LC-BMs) are a common complication in patients with lung cancer and are associated with poor prognosis. Despite advances in lung cancer therapies, the standa...

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...

Critical and Differential Roles of eIF4A1 and eIF4A2 in B-Cell Development and Function Academic Background In mammalian cells, translation initiation is a crucial step in protein synthesis, where the eukaryotic initiation factor 4A (eIF4A) plays a pivotal role. eIF4A is an ATP-dependent RNA helicase that unwinds secondary structures in the 5’ untr...

Academic Background and Problem Statement Loss-of-Function (LOF) mutations in Tumor Suppressor Genes (TSGs) are prevalent in cancer. However, therapeutic strategies directly targeting these mutations are challenging due to the loss or reduction of encoded protein function, which in normal states plays a role in inhibiting aberrant cell proliferatio...

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer Academic Background Breast cancer is one of the most common cancers in women, and endocrine therapy (e.g., tamoxifen) is the standard treatment for estrogen receptor α (ER)-positive ...

Diffusion-Based Feature Augmentation: A Novel Approach for Multiple Instance Learning in Whole Slide Images Academic Background and Research Motivation In computational pathology, effectively analyzing Whole Slide Images (WSIs) is a burgeoning area of research. WSIs are ultra-high-resolution images with a broad field of view and are widely employed...

The Relationship Between Social Risks and Cancer Screening Adherence Among U.S. Adults Academic Background Cancer screening is a critical tool for the early detection and prevention of cancer, significantly improving treatment outcomes and reducing mortality rates. However, despite recommendations from various U.S. health agencies for colorectal, l...

Academic Background Prostate cancer is one of the most common cancers in men worldwide, particularly in Western countries. Despite advances in early diagnosis and treatment significantly improving survival rates, cancer recurrence remains a major clinical challenge. This is particularly true for patients with high-risk nonmetastatic hormone-sensiti...

Economic Evaluation of Breast Cancer Screening: A Study Based on Digital Mammography in Canada Academic Background Breast cancer (BC) is one of the most commonly diagnosed cancers in women and the second leading cause of cancer-related deaths in North America. Although significant progress has been made in breast cancer treatment over the past deca...