Interactive Mechanisms Between Cancer Cells and Macrophages Facilitate Pancreatic Cancer Cachexia Background Pancreatic cancer is currently the third leading cause of cancer-related death in the United States and is expected to become the second leading cause of cancer death within the next decade. Unfortunately, more than 80% of pancreatic cancer ...

Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer Authors Ningning Niu, Qingshen Xu, Wang Zheng, …, Kurong Jiang, Fengshi Yu, Xue Xu Jing published an article titled “Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts He...

Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...

Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...

Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...

Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...

Research Report on the Analysis of Immunological Characteristics of Peripheral Blood in Cancer Patients Cancer is a major and pervasive health problem globally. Despite significant advances in cancer treatment in recent years, many challenges remain, including how to accurately predict patients’ responses to various treatments. Immunotherapy, parti...

Analysis of Intratumor Heterogeneity in Liver Cancer Using Pharmacogenomics: A Study Based on a Large-Scale Organoid Biobank Academic Background Primary liver cancer (PLC) is the third leading cause of cancer-related deaths worldwide, mainly comprising hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and a mixed form called co...