Immunotherapy Drives Mesenchymal Transition and Tumor Microenvironment Immune Response in Glioblastoma Introduction Glioblastoma is a highly malignant brain tumor with no curative treatment currently available. Although immunotherapy has shown efficacy in other cancer types, the response in glioblastoma patients is limited. Investigating the effect...

Introduction Chordoma is a rare and locally aggressive mesenchymal tumor, believed to originate from the remnant tissues of the primitive notochord. The incidence of chordoma is approximately 0.8 per million, with a predilection for the sacral and skull base regions. Currently, the optimal treatment strategy is maximal safe surgical resection follo...

The human genome-encoded triggering receptor expressed on myeloid cells 2 (TREM2) was initially thought to play a role primarily in the central nervous system, participating in the functional regulation of microglia. In recent years, researchers have found that TREM2 is also expressed in peripheral tumors and may promote tumor progression. However,...

Meningiomas are the most common primary intracranial tumors in adults, and their incidence is rising with an aging population and the widespread use of neuroimaging examinations. While most meningiomas are benign, a small portion exhibit biological invasiveness, leading to severe neurological complications and death. In recent years, significant pr...

EDA2R Elevation in Liquid Biopsy Reflects Acute Brain Injury after Cranial Radiation Background Cranial radiation therapy is the standard treatment for advanced brain tumors and metastases, but it leads to devastating neurocognitive impairments, especially in childhood cancer survivors. As the number of childhood brain cancer survivors continues to...

Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...

This is a phase I clinical trial that explored the safety of preoperative single-fraction stereotactic radiosurgery (SRS) with dose escalation for patients with brain metastases. The background of this study is that for brain metastases larger than 2cm in diameter, surgery alone or single-fraction SRS alone is difficult to achieve ideal local contr...

This academic paper reports a study on exosomes in patients with glioblastoma. The study explored the potential application of exosomes as biomarkers in the diagnosis, prognosis, and treatment response monitoring of glioblastoma. Academic Background: Glioblastoma is an invasive brain tumor, and despite comprehensive treatments such as surgery, chem...

In this research paper from the journal Neuro-Oncology, the researchers investigated the relationship between the residual tumor cells at the resection margin after surgical removal and the progression-free survival (PFS) and overall survival (OS) in patients with wildtype isocitrate dehydrogenase (IDH wildtype) glioblastoma (GBM). The authors are ...

Review of Two New Studies on ONC201 Treatment for H3K27M-Mutant Diffuse Midline Glioma (H3K27M-DMG) This review reports on two new studies investigating the small molecule compound ONC201 for the treatment of H3K27M-mutant diffuse midline glioma (H3K27M-DMG). Background: H3K27M-DMG is an aggressive primary brain tumor that predominantly affects chi...