A Panoramic View of Whole Genome Repetitive Sequences in Cancer and Circulating Free DNA Research Background and Significance Throughout the development of cancer and other diseases, genetic changes in repetitive sequences within the genome are a significant characteristic. However, standard sequencing methods struggle to effectively characterize t...
Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...
Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...
Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...
Interactive Mechanisms Between Cancer Cells and Macrophages Facilitate Pancreatic Cancer Cachexia Background Pancreatic cancer is currently the third leading cause of cancer-related death in the United States and is expected to become the second leading cause of cancer death within the next decade. Unfortunately, more than 80% of pancreatic cancer ...
Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer Authors Ningning Niu, Qingshen Xu, Wang Zheng, …, Kurong Jiang, Fengshi Yu, Xue Xu Jing published an article titled “Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts He...
Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...
Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...
Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...
ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...