Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...

Academic Background and Problem Statement Gastric Cancer (GC) is one of the most common cancers worldwide, with approximately 1.1 million new cases diagnosed in 2020. Although advancements in early detection, surgical techniques, and oncology have led to a decline in GC mortality, the treatment of advanced or metastatic GC remains a significant cha...

Metabolic Imaging Distinguishes Ovarian Cancer Subtypes and Detects Their Early and Variable Responses to Treatment Academic Background Ovarian cancer is one of the leading causes of cancer-related deaths in women, with high-grade serous ovarian cancer (HGSOC) being the most common lethal subtype. In recent years, metabolic subtypes have been ident...

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma Academic Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies worldwide, with increasing incidence and mortality rates, particularly in advanced stages. Despite significant prog...

TFF3 Drives Hippo-Dependent EGFR-TKI Resistance in Lung Adenocarcinoma Academic Background Lung adenocarcinoma (LUAD) is one of the most common subtypes of non-small cell lung cancer (NSCLC), with frequent mutations in the epidermal growth factor receptor (EGFR). Since 2013, EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and o...

Academic Research Report: MCL1 Copy Number Gain as a Therapeutic Target for Osteosarcoma Academic Background Osteosarcoma (OS) is a primary malignant bone tumor that predominantly affects children and adolescents. Although the treatment regimen combining surgery with chemotherapy was established in the 1970s and remains the standard therapy, progre...

TRIB3 Promotes Multiple Myeloma Progression by Stabilizing SSRP1 via USP10-Mediated Deubiquitination Academic Background Multiple Myeloma (MM) is the second most common hematologic malignancy globally, characterized by aggressive progression, frequent relapse, and resistance to therapy. Although current multi-drug combination therapies have signifi...

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression Academic Background Ovarian cancer (OC) is one of the most lethal cancers in the female reproductive system, with complex pathogenesis and limited treatment options. The epidermal growth factor receptor (EGFR) signaling pathway is widely dysregulated in various can...

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...