Inducing Immune Tolerance through Peripheral Clonal Deletion Targeting PD-1 Expressing Cells Background Introduction The establishment of T-cell receptor (TCR) repertoire through thymic negative selection is a key process for achieving self-tolerance and acquired tolerance post-organ transplantation. However, it remains unclear whether the specific...

Report: Intrinsic Role of m6A Reader Protein YTHDF2 in Regulating Tumor Immune Evasion Background Introduction In recent years, immunotherapy has become a hotspot in the field of tumor treatment, attracting attention for its ability to break through immune suppression barriers or enhance existing anti-tumor immunity. However, despite some successes...

Tumor Immunology Research: The Exhausted State of CD8+ T Cells in Tumors In recent years, immunotherapy has achieved significant progress in the field of tumor treatment. However, tracking the behavior of lymphocytes following antigen signals remains challenging. This study aims to address this issue by developing Antigen Receptor Signaling Reporte...

Cancer Immunology Research: Overexpression of MALAT1 Drives Lung Adenocarcinoma Metastasis Through Inflammatory Reprogramming Background Introduction MALAT1 (Metastasis-associated Lung Adenocarcinoma Transcript 1) is a long noncoding RNA (lncRNA) closely linked to tumor progression and metastasis in several cancers, including lung adenocarcinoma (L...

Cancer Immunology Lactate-SREBP2 Signaling Axis-Driven Tolerogenic Dendritic Cell Maturation and Its Role in Promoting Cancer Progression Background In cancer, conventional dendritic cells (DCs) are key mediators of anti-tumor immunity. However, cancer has evolved mechanisms that render DCs ineffective in the tumor microenvironment (TME), and these...

MAIT Cells Monitor Gut Microbiota Dysbiosis and Protect the Host in Colitis Research Background As research on the relationship between the gut and host health deepens, changes in the gut microbiome are closely related to various human diseases, especially inflammatory bowel disease (IBD). Currently, it is recognized that under homeostatic conditio...

Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...

YAP Inhibits the TEAD-NF-κB Complex and Suppresses the Growth of Clear Cell Renal Cell Carcinoma Research Background Conventionally, the Hippo signaling pathway inhibits YAP-TEAD transcriptional complexes by keeping the transcriptional coactivator YAP phosphorylated and retained in the cytoplasm, thereby impeding tumor growth. However, researchers ...

In the context of today’s rapid advancement in science and technology, immunotherapy with natural killer (NK) cells has attracted widespread attention in the scientific community for their potential advantages in combating tumors and viral infections. Especially, the discovery of memory-like NK cells has brought new hope for NK cells as an anticanc...

Study of Neuroepithelial Genetic Markers and Prognosis in High-Grade Gliomas Background and Research Motivation High-grade gliomas are highly malignant brain tumors with generally poor patient prognosis. Previous preclinical model studies have suggested that interactions between neural and tumor cells drive tumor growth, but clinical validation of ...