Machine Learning and Confirmatory Factor Analysis Show that Buprenorphine Alters Motor and Anxiety-like Behaviors in Male, Female, and Obese C57BL/6J Mice

In recent years, with the global increase in drug abuse, particularly opioids, scientists have become increasingly focused on the neurobehavioral effects of such substances. Among them, buprenorphine, an opioid, is widely used for medication-assisted treatment of opioid addiction. However, beyond its analgesic and addiction treatment effects, bupre...

Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Modulation of Electrical Synapses and Excitability by Dopamine Receptors in the Thalamic Reticular Nucleus Academic Background The Thalamic Reticular Nucleus (TRN) is a thin shell of γ-aminobutyric acid (GABA)ergic inhibitory neurons in the thalamus. These neurons are coupled via gap junctions and regulate the transmission of sensory information fr...

Increased Robustness and Adaptation to Simultaneous Temperature and Elevated Extracellular Potassium in the Pyloric Rhythm of the Crab, Cancer Borealis

Increased Robustness and Adaptation of the Crab Pyloric Rhythm to Simultaneous Temperature and Elevated Extracellular Potassium Academic Background In nature, animals often face multiple simultaneous environmental perturbations, which may include temperature fluctuations, pH variations, salinity changes, and alterations in extracellular potassium c...

The Discharge Characteristics of Motor Units Innervating Functionally Paralyzed Muscles

Study on the Discharge Characteristics of Motor Neurons Innervating Paralyzed Muscles after Spinal Cord Injury Academic Background Spinal Cord Injury (SCI) is a severe neurological injury that typically leads to the loss of motor and sensory functions below the injury level. Although patients clinically diagnosed with complete SCI are considered un...

Repeated Social Stress Increases Posterior Medial Amygdala Neuronal Activity in Stress-Susceptible Adult Male Rats

Effects of Repeated Social Stress on Neuronal Activity in the Posterior Medial Amygdala of Male Rats Background Social stress plays a crucial role in social behavior and mental health. Chronic social stress not only leads to changes in individual behavior but is also closely related to the development of various psychiatric disorders, such as anxie...

Applications of Transcranial Direct Current Stimulation over Vagus Nerve on Dysphagia after Stroke

Research on Transcranial Direct Current Stimulation Over Vagus Nerve for Post-Stroke Dysphagia Academic Background Stroke is the second leading cause of death worldwide, and survivors often face a range of complications, among which dysphagia is particularly common, with an incidence rate ranging from 27% to 64%. Dysphagia can lead to serious probl...

Sensory Processing in the Chilean Brush-tailed Mouse (Octodon degus): A Diurnal Precocial Rodent as a New Model to Study Visual Receptive Field Properties of Superior Colliculus Neurons

Academic Background The visual system is a crucial component for animals to perceive their external environment, and research on its development and function is essential for understanding the sensory mechanisms of mammals. However, traditional studies have predominantly relied on nocturnal or crepuscular laboratory rodents, such as mice, rats, and...

Motor Decision-Making under Uncertainty and Time Pressure

Research on Motor Decision-Making under Uncertainty and Time Pressure Academic Background In daily life, animals and humans often need to choose the most appropriate action from multiple possible options. However, how to plan and execute these actions under conditions of goal uncertainty and time pressure remains an incomplete question in neuroscie...

Adaptive Quantized Control for a Class of Hysteresis Nonlinear System with Irregular Constraints and Its Application to Piezoelectric Positioning Stage

Adaptive Quantized Control Research for Hysteresis Nonlinear Systems in Piezoelectric Positioning Stages Background Introduction In modern high-precision positioning systems, smart materials (such as piezoelectric ceramics) are widely used in micro/nano manufacturing and soft robotics due to their excellent performance. However, the inherent hyster...

Exoskeleton-Assisted Stance and Kneeling Balance and Work Task Evaluation in Construction

Balance and Task Evaluation of Construction Workers Assisted by Knee Exoskeletons Background Introduction Construction workers face serious safety and health risks in hazardous working environments, especially when working at heights. Prolonged standing and kneeling postures can lead to knee injuries, musculoskeletal disorders, and visual disturban...