A Practical Micropipette-Image Calibration Method for Somatic Cell Microinjection

Micropipette-Image Calibration Method Based on Micromanipulation System for Somatic Cell Microinjection Research Background Microinjection is a technique that employs a fine micropipette to inject a precise amount of genetic material, drugs, or other exogenous substances directly into cells or tissues. This technology plays a pivotal role in biomed...

Effective Probabilistic Neural Networks Model for Model-Based Reinforcement Learning in USV

A New Approach to Model Predictive Control for Unmanned Surface Vehicles (USV): A Probabilistic Neural Network-Based MBRL Framework Academic Background Unmanned Surface Vehicles (USVs) have seen rapid development in recent years within the field of marine science, finding extensive applications in scenarios such as marine transportation, environmen...

A Restricted-Learning Network with Observation Credibility Inference for Few-Shot Degradation Modeling

A Restricted-Learning Network with Observation Credibility Inference for Few-Shot Degradation Modeling Academic Background In complex engineering systems, multiple sensors are widely used to monitor the degradation processes of equipment and predict their Remaining Useful Life (RUL). However, ensuring predictive performance remains challenging when...

Oral-Anatomical Knowledge-Informed Semi-Supervised Learning for 3D Dental CBCT Segmentation and Lesion Detection

Academic Background and Research Motivation In the field of dental healthcare, Cone Beam Computed Tomography (CBCT) is a widely used three-dimensional imaging technique. CBCT provides three-dimensional images of the oral cavity and is particularly effective in diagnosing odontogenic lesions. However, the segmentation of CBCT images—labeling each vo...

Influence of Visual-Inertial Sensor-to-Segment Calibration on Upper Limb Joint Angles Estimation

Influence of Visual-Inertial Sensor-to-Segment Calibration on Upper Limb Joint Angles Estimation

Research on Upper Limb Joint Angle Estimation Based on Visual-Inertial Sensors and the Impact of Calibration Methods Academic Background Upper limb dysfunction, especially in post-stroke patients, significantly impacts their ability to perform daily activities. Rehabilitation training is a critical method for restoring upper limb function, but its ...

Adiporon Ameliorates the Progression of Heart Failure with Preserved Ejection Fraction via Mitigating Lipid Accumulation and Fibrosis

Adiporon Ameliorates the Progression of Heart Failure with Preserved Ejection Fraction (HFpEF) by Reducing Lipid Accumulation and Fibrosis Research Background Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, often coexisting with metabolic disorders such as obesity, diabetes, and hypertension. Althoug...

Multi-Task Aquatic Toxicity Prediction Model Based on Multi-Level Features Fusion

Academic Background With the growing threat of organic compounds to environmental pollution, studying the toxic responses of different aquatic organisms to these compounds has become crucial. Such research not only helps assess the potential ecological impacts of pollutants on the overall aquatic ecosystem but also provides significant scientific f...

Hybridization-Based Discovery of Novel Quinazoline-2-Indolinone Derivatives as Potent and Selective PI3Kα Inhibitors

Research and Development of a Novel PI3Kα Inhibitor: Molecular Hybridization Technology Leads to a Breakthrough in Lung Cancer Treatment Academic Background Cancer, particularly non-small cell lung cancer (NSCLC), is the second leading cause of death worldwide. Currently, chemotherapy is the primary treatment method, but due to its lack of targetin...

Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-Dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway

Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway Background Vascular calcification is a pathological process involving the deposition of hydroxyapatite in the vessel wall, often associated with atherosclerotic cardiovascular disease and chronic kidney...

Mechanism of GADD45B-Mediated Inflammation and Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease

DNA Hypomethylation-Mediated Upregulation of GADD45B Facilitates Airway Inflammation and Epithelial Cell Senescence in COPD Academic Background Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease characterized by chronic airway inflammation and irreversible airflow limitation, and it is one of the leading causes of death worldwi...