The Role of Electroencephalography in Epilepsy Research: From Seizures to Interictal Activity and Comorbidities Academic Background Since the early 20th century, electroencephalography (EEG) has been a key tool in epilepsy research. EEG technology not only helps scientists record and analyze brain signals but also reveals the pathophysiological mec...

Neurocritical Care Organization in Low- and Middle-Income Countries Academic Background and Problem Statement Neurocritical care (NCC) has rapidly evolved over the past few decades as a distinct subspecialty of critical care medicine. Evidence shows that patients with acute brain injuries have significantly improved outcomes when treated in dedicat...

Promoting Healthy Longevity: Implementation Recommendations for the Hevolution Alliance for Aging Biomarkers Initiative Academic Background and Research Motivation With the intensification of global population aging, human life expectancy has significantly increased, but the growth in healthy life expectancy (i.e., years lived in good health) has b...

Serum Neurofilament Light Chain and Cognitive Performance in Women with and without HIV: A Longitudinal Study Over Approximately 8 Years Research Background With the widespread use of highly active antiretroviral therapy (ART), the life expectancy of individuals infected with human immunodeficiency virus (HIV) has significantly increased. However, ...

Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases Academic Background Neurodegenerative diseases (such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease) are characterized by neuronal death and gradual loss of function, leading to the deterioration of cognitive, ...

Research Background and Problem Introduction Protein O-GlcNAc glycosylation is an important post-translational modification that plays a critical role in cellular metabolic plasticity. Aberrant O-GlcNAc glycosylation levels have been observed in various cancers, including endometrial cancer (EC), a common malignancy in women. However, clinical char...

Cancer Cells Evade Immune Cell-Induced Ferroptosis via Fatty Acid Binding Protein 7 Background Introduction Cancer creates an immunosuppressive environment that hinders immune responses, allowing tumors to grow and resist treatment. The immune system combats this by inducing ferroptosis in tumor cells through CD8+ T cells. Ferroptosis is a type of ...

Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...

UC-II® Undenatured Type II Collagen Retention in Functional Food and Beverage Processing Academic Background Collagen is widely used in the food and beverage industry to enhance the nutritional and health value of products. Specifically, undenatured type II collagen (UC-II®) has garnered attention for its potential benefits to joint health. However...

Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study Academic Background Introduction Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor, accounting for nearly 50% of all primary brain tumors in adults. It primarily originates from astro...