The Impact of a Statewide Regionalization Policy on Travel Distance for Initial Breast Cancer Surgery Academic Background Breast cancer is one of the most common cancers among women globally, and the quality of treatment and patient survival rates are closely related to the allocation of medical resources. Studies have shown that high-volume medica...

Academic Background Acute Myeloid Leukemia (AML) is a malignant blood disorder, with the core of its treatment being induction chemotherapy, typically involving a combination of cytarabine and anthracyclines (such as daunorubicin). Although this treatment regimen has been in use since the 1980s, questions regarding the optimal dose of daunorubicin ...

Academic Background Acute leukemia is a malignant hematologic disease caused by genetic mutations in hematopoietic cells, characterized by a block in differentiation during hematopoiesis and uncontrolled cellular proliferation. Among these, KMT2A gene rearrangements (KMT2A-rearranged, KMT2Ar) occur in up to 10% of acute leukemias in children and ad...

Darolutamide in Combination with Androgen-Deprivation Therapy in Patients with Metastatic Hormone-Sensitive Prostate Cancer from the Phase III ARANOTE Trial Academic Background Metastatic hormone-sensitive prostate cancer (mHSPC) is a common type of prostate cancer. Patients typically respond to androgen-deprivation therapy (ADT) for a period of ti...

Efficacy of Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases Academic Background Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children. Despite advancements in treatment, the prognosis for patients with metastatic RMS remains poor, especially for those with lung metastases, whose survival rates are significantly lower th...

Revumenib Alters the Treatment Landscape for KMT2A-Rearranged Leukemia Academic Background Leukemia is a malignant disease caused by abnormalities in the hematopoietic system, with KMT2A-rearranged (KMT2A-r) leukemia being a common subtype, particularly in pediatric and adult acute myeloid leukemia (AML). Rearrangements of the KMT2A gene (lysine me...

Academic Background Caregivers of patients with Primary Malignant Brain Tumors (PMBT) face significant psychological distress. PMBT is not only an incurable cancer but also accompanied by degenerative neurological conditions, leading caregivers to cope with the gradual loss of the patient’s physical functions and irreversible changes in personality...

Academic Background and Problem Statement Epithelial Ovarian Cancer (EOC) remains one of the leading causes of death among gynecologic malignancies. Although the incorporation of molecularly targeted therapies, such as bevacizumab and PARP inhibitors, has improved Progression-Free Survival (PFS) and, in some cases, Overall Survival (OS), many patie...

Academic Background and Problem Acute lymphoblastic leukemia (ALL) is a malignant hematologic disease, particularly challenging to treat in older patients, with limited treatment options and poor outcomes. Traditional chemotherapy regimens yield long-term survival rates of only 20%-30% in elderly patients. Therefore, finding more effective and bett...

Impact of Adjuvant Chemotherapy on Resected Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: Results from an International Multicenter Study Academic Background Intraductal Papillary Mucinous Neoplasm (IPMN) is the most common type of pancreatic cyst, and its incidence and prevalence have been increasing due to the widespread use ...