Structural Basis of LSD Recognition in Dopamine D1 Receptors Research Background and Problem Statement LSD (lysergic acid diethylamide) is a well-known hallucinogen that primarily exerts profound cognitive and perceptual effects by acting on various neurotransmitter receptors, including serotonin (5-HT) receptors and dopamine receptors. The 5-HT2A ...

With the advancement of neuroscience research, the crucial role of N-methyl-D-aspartate receptors (NMDA receptors, NMDAR) in neurotransmission and cognitive functions has become increasingly clear. NMDARs are a type of ionotropic glutamate receptor that play an important role in neuronal synapses, responsible for rapid excitatory transmission and s...

Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...

In a study titled “Visual Experience Reduces the Spatial Redundancy between Cortical Feedback Inputs and Primary Visual Cortex Neurons,” Rodrigo F. Dias, Radhika Rajan, and their team explored how visual experience influences the spatial redundancy of cortical feedback pathways. This research was carried out by scientists from the Champalimaud Neur...

Study on the Effect of Glucose Regulation on Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Patients with Fatty Liver Disease Research Background and Significance Metabolic-dysfunction-associated Steatotic Liver Disease (MASLD) has become one of the major challenges in global health in the 21st century. This condition is often acc...

Endothelial Cells Influence Insulin Sensitivity Through Metabolic Regulation of Resident Macrophages In recent years, metabolic diseases, especially insulin resistance and diabetes, have become significant global health issues. Muscle tissue, being one of the main organs for glucose metabolism in the human body, has its insulin sensitivity closely ...

Paper Report: The Role of MDH2 in Epitranscriptomic Metabolic Regulation of Glioblastoma Stem Cells Introduction and Background Glioblastoma (GBM) is the most common and lethal primary brain malignant tumor in adults. GBM cells utilize a metabolic pathway known as the Warburg effect, which involves increased glucose uptake through aerobic glycolysi...

Research Report on the Relationship Between High Protein Diet and Liver Fat Synthesis Background and Significance Globally, the prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is gradually increasing, becoming a common issue among people with obesity and insulin resistance. The pathological development of this disease...

Fructose Promotes Colorectal Cancer Growth by Modulating Tumor-Associated Macrophage Polarization Introduction In recent years, fructose intake has dramatically increased worldwide and is closely associated with obesity and metabolic syndrome, both of which are recognized risk factors for cancer development. Although previous studies have shown tha...

Background and Research Motivation Globally, Type 2 Diabetes (T2D) is a common metabolic disease characterized by the combined effects of genetic and environmental factors leading to dysfunction and/or cell death of pancreatic β-cells, resulting in insufficient insulin secretion. Based on findings from Genome-Wide Association Studies (GWAS), over 6...