A Portable, Sprayable, Highly Malleable, Elastic, and Hydrophobic Antibacterial Fibrous Wound Dressing for Infected Wound Healing

Chemistry, Nanoscience, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Infectious Diseases, Life Sciences, Bioengineering,
wound dressing   antibacterial   hydrophobic   malleability   solution blow spinning   infected wound   wound healing  

Academic Background Wound infection is a significant concern for patients and healthcare professionals worldwide, particularly in the management of severe wounds. Inappropriate dressings can increase the risk of infection, prolong healing time, and even lead to higher mortality rates and economic burdens. Traditional wound dressings, such as gauze ...

Bioactive MgO/MgCO3/Polycaprolactone Multi-Gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling

Chemistry, Polymer Chemistry, Materials Chemistry, Materials Science, Metallic Materials, Medicine, Neurology,
magnesium   multi-gradient fibers   Schwann cells   Wnt signaling pathway   peripheral nerve regeneration  

Study on Peripheral Nerve Regeneration Based on Multi-Gradient MgO/MgCO₃/PCL Nanofiber Membranes Academic Background Peripheral nerve defects are a common and complex orthopedic issue in clinical practice, with limited efficacy of current treatments. The insufficient proliferation and dysfunction of Schwann cells within nerve scaffolds are key fact...

Super-Elastic Phenylalanine Dipeptide Crystal Fibers Enable Monolithic Stretchable Piezoelectrics for Wearable and Implantable Bioelectronics

Chemistry, Nanoscience, Polymer Chemistry, Materials Chemistry, Materials Science, Medicine, Life Sciences, Bioengineering,
piezoelectric materials   nanoconfinement self-assembly   phenylalanine dipeptide   stretchable sensor   wireless motion monitor  

Super-Elastic Phenylalanine Dipeptide Crystal Fibers in Wearable and Implantable Bioelectronics Background With the rapid development of flexible bioelectronics, the development of piezoelectric materials and devices with high elasticity, breathability, and the ability to achieve conformal deformation with the human body has become an important res...

A Polyphenol–Metal Network of Propyl Gallate Gallium/Hafnium Oxide on Polyimide Fibers for Facilitating Ligament–Bone Healing

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Orthopedics, Sports Medicine, Life Sciences, Bioengineering,
polyimide fiber   artificial ligament   osteogenesis   anti-bacteria   anti-inflammation   ligament–bone healing  

Study on Surface Modification of Polyimide Fibers to Promote Ligament-Bone Healing Academic Background Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries worldwide, with approximately 1 in 1,250 people requiring ACL reconstruction surgery each year. Currently, the main methods for ACL reconstruction include autografts...

Neoadjuvant Nivolumab and Chemotherapy in Early Estrogen Receptor-Positive Breast Cancer: A Randomized Phase 3 Trial

Medicine, Oncology,
breast cancer   neoadjuvant chemotherapy   nivolumab   estrogen receptor-positive   randomized trial  

Neoadjuvant Nivolumab and Chemotherapy in Early Estrogen Receptor-Positive Breast Cancer Academic Background Breast cancer is one of the most common cancers among women worldwide, with estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer accounting for the majority of cases. Although ER+/HER2−...

Multi-omics-based Mapping of Decidualization Resistance in Patients with a History of Severe Preeclampsia

Medicine, Obstetrics and Gynecology, Life Sciences,
Decidualization resistance   Severe preeclampsia   Multi-omics analysis   Endometrium   Cell-cell communication  

Multi-omics technology reveals the mechanism of endometrial decidualization resistance in patients with severe preeclampsia Academic background Preeclampsia (PE) is a common and serious complication during pregnancy, primarily characterized by hypertension, proteinuria, and dysfunction of other organs, posing a significant threat to maternal and fe...

Pembrolizumab and Chemotherapy in High-Risk, Early-Stage, ER+/HER2− Breast Cancer: A Randomized Phase 3 Trial

Medicine, Oncology,
breast cancer   pembrolizumab   chemotherapy   randomized trial   pathological complete response  

Pembrolizumab Combined with Chemotherapy in High-Risk, Early-Stage ER+/HER2− Breast Cancer: A Randomized Phase 3 Trial Academic Background Breast cancer is one of the most common cancers among women worldwide, with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2−) breast cancer accounting for a significant pro...

Genomic Reanalysis of a Pan-European Rare-Disease Resource Yields New Diagnoses

Medicine, Life Sciences, Genetics,
rare diseases   genomic reanalysis   European collaboration   diagnostic yield   genetic variants  

European Genomic Reanalysis of Rare Diseases: New Diagnoses and Future Blueprint Academic Background Rare diseases are defined as conditions affecting a very small proportion of the population, with the European Union setting the threshold at fewer than 50 individuals per 100,000. Despite the vast diversity of rare diseases (over 6,000 types), more...

Evaluating Generalizability of Oncology Trial Results to Real-World Patients Using Machine Learning-Based Trial Emulations

Information Science, Artificial Intelligence, Medicine, Oncology,
oncology   randomized controlled trials   machine learning   generalizability   real-world data   prognostic models   survival analysis  

Evaluation of the Generalizability of Oncology Trial Results Using Machine Learning-Based Trial Emulations Academic Background Randomized Controlled Trials (RCTs) are the gold standard for evaluating the efficacy of anti-cancer drugs, but their results often cannot be directly generalized to real-world oncology patients. RCTs typically employ stric...

Clinicogenomic Landscape of Pancreatic Adenocarcinoma Identifies KRAS Mutant Dosage as Prognostic of Overall Survival

Medicine, Hepatobiliary System, Gastroenterology, Oncology,
pancreatic cancer   KRAS mutation   genomic landscape   prognostic marker   clinical study  

Clinicogenomic Landscape of Pancreatic Ductal Adenocarcinoma: The Prognostic Role of KRAS Mutation Dosage Academic Background Pancreatic ductal adenocarcinoma (PDAC), the most common histological type of pancreatic cancer, is the third leading cause of cancer-related mortality and has the lowest five-year survival rate among all cancer types. Over ...