Skin wound healing is a complex biological process involving the coordination of cellular, molecular, and physiological events. Although traditional treatment methods can promote wound closure to some extent, their efficacy is often unsatisfactory in chronic wounds or complex trauma environments, particularly in controlling infections and inflammat...
Academic Background Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC) are among the most common types of skin cancer globally. Although the mortality rates of these cancers are relatively low, their incidence has been increasing year by year, significantly impacting patients’ quality of life and potentially leading to prematur...
Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain worldwide, significantly impacting patients’ quality of life. IVDD is often accompanied by inflammatory responses, leading to the degradation of the extracellular matrix (ECM) and structural damage. Although cell therapies, such as mesenchymal stem cells (MSCs), h...
Cervical cancer and endometrial cancer are significant challenges in women’s healthcare, with high mortality rates and limited treatment options making related research particularly important. Traditional two-dimensional (2D) cell screening models can provide information on the effects of drugs on single cells but fail to capture multicellular inte...
Obesity is a growing global health issue, closely linked to metabolic diseases such as cardiovascular diseases and diabetes, as well as lymphatic dysfunction. The lymphatic system plays a crucial role in maintaining fluid balance, immune responses, and fat metabolism. However, lymphatic function is often impaired in obese patients, leading to compl...
Endothelial cells play a crucial role in the vascular system, regulating hemostasis, vasodilation, immune responses, and inflammation through intercellular junctions (IJs). However, excessive mechanical loading can lead to endothelial cell damage and endothelial barrier dysfunction. Understanding the dynamic rupture mechanisms of intercellular junc...
In recent years, autophagy, as a crucial intracellular degradation and recycling mechanism, has played a key role in maintaining cellular homeostasis and responding to various stress conditions. Particularly in renal proximal tubular epithelial cells, autophagy activity is essential for coping with common renal injuries such as ischemia, toxic dama...
In pathological conditions, alterations in tissue mechanical properties are one of the prominent features of many diseases, such as cancer. The tumor vascular system plays a critical role in tumor growth, but its structure and function often become abnormal, manifesting as disorganized, tortuous, and leaky blood vessels. Research has shown that the...
Academic Background Vascular Smooth Muscle Cells (VSMCs) in the normal aortic wall regulate vascular contraction and dilation. However, under pathological conditions, VSMCs transition from a contractile phenotype to a synthetic phenotype and actively participate in the remodeling of the aortic wall. Although many in vitro studies have reported the ...
Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths in the United States, with liver metastasis being a common occurrence. Before tumor metastasis, the formation of the Pre-Metastatic Niche (PMN) is a critical process. PMN involves the activation of key liver-resident cells, including fibroblast-like stellate cells and mac...