New Discovery in the Mechanism of Radioresistance in Esophageal Squamous Cell Carcinoma: The Role of the RFC4 Gene Academic Background Esophageal squamous cell carcinoma (ESCC) is one of the most common gastrointestinal malignancies in China, and radiotherapy is a crucial treatment modality. However, radioresistance in tumor cells is a major cause ...

Mettl14 Promotes Ferroptosis in Vascular Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4 Academic Background Thoracic aortic aneurysm (TAA) is a severe vascular disease that often leads to aortic rupture and acute dissection, with extremely high mortality rates. Currently, the primary treatment for T...

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

Bone Marrow-Derived NGFR+ Dendritic Cells Regulate Arterial Remodeling Background Introduction Atherosclerosis is the primary pathological basis of cardiovascular disease, and its incidence continues to rise globally. Although extensive research has revealed the pathogenesis of atherosclerosis and led to the development of various therapeutic drugs...

Syntaxin 4-Enhanced Plasma Membrane Repair is Independent of Dysferlin in Skeletal Muscle Background Introduction Plasma membrane repair (PMR) is a crucial process for cells to maintain membrane integrity, preventing cell death, especially in vital organs such as skeletal muscle. Dysferlin, a sarcolemmal calcium-binding protein, has been shown to p...

Mechanism Study of p300 Maintaining Primordial Follicle Activation by Inhibiting VEGFA Transcription Academic Background In the female reproductive system, primordial follicles (PFs) are the earliest formed follicles in the ovary, remaining dormant and awaiting activation to enter the growth phase. The activation of primordial follicles is a key fa...

Mechanism Study of Dapagliflozin Improving Diabetic Nephropathy via the Gut-Kidney Axis Academic Background Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, with approximately 40% of individuals with type 1 or type 2 diabetes developing DN in the advanced stages of the disease. Although clinical managemen...

Identification of Polycystin 2 Missense Mutants Targeted for Endoplasmic Reticulum-Associated Degradation Academic Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder that ultimately leads to end-stage renal disease. ADPKD primarily arises from mutations in the PKD1 and PKD2 genes, which encode Polycystin 1 ...

Histone Lactylation Promotes Endometriosis Progression by Upregulating CTPS1 SUMOylation Academic Background Endometriosis is a common reproductive endocrine disease affecting approximately 10% of women of reproductive age worldwide. Its main symptoms include dysmenorrhea, chronic pelvic pain, infertility, and menstrual abnormalities. Although the ...

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...