The Direct Link between Cytosolic pH and Environmental Signals, Insulin Processing, and Secretion in Pancreatic β Cells Background Pancreatic β cells respond to glucose fluctuations by regulating insulin processing and secretion. However, how this process is finely tuned within a complex and variable microenvironment, and whether its dysfunction is...
Myocardial Infarction Accelerates the Progression of Metabolic Dysfunction-Associated Steatohepatitis by Inducing Immune Inflammatory Response and Periostin Background and Study Motivation Metabolic-associated steatohepatitis (MASLD, formerly NAFLD) is one of the most common chronic liver diseases worldwide, affecting about 25% of the adult populat...
Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...
Imaging Study of Brain Glucose Metabolism in Patients with Pyruvate Dehydrogenase Deficiency Background In modern mitochondrial medicine, evaluating the spectrum of brain diseases has been a limiting challenge. This limitation hinders our ability to understand the mechanisms behind the imaging phenotypes of the brains of mitochondrial disease patie...
New Scientific Discovery: The 5:2 Intermittent Fasting Regimen Improves Non-Alcoholic Steatohepatitis and Reduces Hepatocellular Carcinoma Occurrence Research Background and Problem Statement Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with its prevalence increasing alongside rising obesity rates. N...
Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...
Browning of Subcutaneous White Adipose Tissue and Skin Repair Efficiency Current scientific research reveals that the participation of various cells is essential in the process of skin repair and regeneration. Among these, adipocytes (fat cells) have attracted attention due to their primary role in energy storage and critical endocrine functions in...
Disruption of Circadian Rhythm Promotes Cancer Metastasis and Myeloid-Derived Suppressor Cell Accumulation Triggered by Intestinal Microbes Academic Background and Research Motivation Cancer metastasis is the leading cause of death for most cancer patients, with colorectal cancer (CRC) drawing significant attention due to its high global incidence ...
Study Report on White Matter Microstructure Changes in Adult-Onset Idiopathic Focal Cervical Dystonia Patients Scientists are dedicated to studying Adult-Onset Idiopathic Focal Cervical Dystonia (AOIFCD), the most common type of idiopathic dystonia in adults. This condition primarily manifests as abnormal neck muscle postures, often accompanied by ...
Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...