This report is based on the following research article: “neutrophil–macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome”, written by Haixia Kang, Ting Liu, Yuanyuan Wang, Wenjuan Bai, Yan Luo, and Jing Wang, published in the journal “Cellular & Molecular Immunology” in ...
Spatiotemporal Regulation of KLF2 and T-bet by Eomesodermin During NK Cell Development I. Research Background Natural Killer (NK) cells are important cells in the immune system, capable of recognizing and killing tumor cells and pathogen-infected cells. The generation and development of NK cells depend on the gradual acquisition of a series of spec...
Research Background Sepsis is a life-threatening organ dysfunction syndrome caused by the body’s abnormal response to microbial infection. It has high morbidity and mortality, mainly due to excessive inflammatory response and metabolic disorders. Studies have shown that myeloid cells (such as monocytes and macrophages) play a key role in the pathog...
Scientific Research Report: The Protective Role of Integrin α4β7 and Type 2 Innate Lymphoid Cells in Nephritis In a recent study, an international research team led by Dr. Seungwon Ryu revealed the critical protective role of integrin α4β7 and Type 2 Innate Lymphoid Cells (ILC2s) in nephritis caused by Systemic Lupus Erythematosus (SLE). The study ...
Academic Report Research Background In recent years, there has been growing interest in individual differences within the fields of psychology and cognitive neuroscience. However, many studies face a replication crisis, particularly evident in research exploring brain-behavior correlations. A key element for replicable individual differences resear...
Humans Need Auditory Experience to Produce Typical Volitional Nonverbal Vocalizations Introduction This research paper explores whether humans require auditory input to produce nonverbal emotional expressions (such as screams and cries). While these nonverbal vocalizations seem to have a strong reflexive basis, many emotional vocalizations are unde...
Targeting STING in Dendritic Cells Alleviates Psoriatic Inflammation Psoriasis is a common chronic inflammatory skin disease primarily caused by abnormal activation of dendritic cells (DCs) and T cells, ultimately leading to increased cytokines such as interleukin (IL)-23 and IL-17A. The cGAS-STING pathway is known to play a key role in psoriatic i...
Research Report: Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G, Exacerbating Sepsis Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The immune system dysfunction accompanying sepsis is primarily triggered by pathogen-associated molecular patterns (PAMPs) and damage-a...
Research Report on the Long-term Relationship between Time Perspective and Life Satisfaction in Adulthood Research Background Time perspective is an important predictor of human well-being. However, time perspective itself changes with development. A future-dominated time perspective gradually gives way to a present and past-focused perspective as ...
Background Introduction In the human visual system, the understanding and navigation of natural scenes are exceptionally outstanding in terms of both complexity and efficiency. This process requires the transformation of incoming sensory information into visual features ranging from low-level to high-level, such as edges, object parts, and objects ...