Improving the Accuracy of Brain Image Analysis in Patients with Idiopathic Normal Pressure Hydrocephalus Using Customized Tissue Probability Maps and Templates Academic Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a common neurological disorder characterized by gait disturbance, cognitive decline, and urinary incontinence. One of t...

New Method for Studying the Coupling Between Cerebrospinal Fluid Flow and Cortical BOLD Signals Academic Background In recent years, the role of cerebrospinal fluid (CSF) in brain waste clearance has garnered significant attention. Traditionally, CSF was thought to primarily serve as a cushion and provide immune surveillance. However, growing evide...

Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...

Numerical Simulation Study of Cerebrospinal Fluid Drainage through Cervical Lymphatic Vessels Background Introduction Cerebrospinal fluid (CSF) is a clear fluid that circulates around the brain and spinal cord, providing physical protection, nutrient supply, and waste clearance for the central nervous system. In recent years, growing evidence sugge...

Application of Automated In Vitro Models in Hydrocephalus Research Background Introduction Hydrocephalus is a neurological condition caused by the accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles. If left untreated, it can lead to severe complications and permanent brain damage. It is estimated that 1 in every 500 newborns is bor...

Study on Cerebrospinal Fluid Flow Dynamics and Its Application in Drug Delivery Background Introduction Cerebrospinal fluid (CSF) plays a crucial role in the human spinal canal, responsible for transporting dissolved nutrients and waste products. Due to its pulsatile nature, CSF flow is influenced by cardiac and respiratory cycles. In recent years,...

Association Between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults: A Research Study Academic Background With the increasing global aging population, the number of dementia patients is rising annually. Early identification of older adults with declining cognitive function and guiding them toward preventive and thera...

Assessment of Brain Endothelial Permeability, Transport, and Flow Background Introduction The blood-brain barrier (BBB) is a critical barrier that protects the brain from harmful substances while also serving as a key obstacle for drug delivery to the brain. The permeability and transport properties of the BBB directly influence the distribution of...

The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...

Non-invasive MRI Study of Blood-Cerebrospinal Fluid Barrier Function in a Mouse Model of Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles. Recent studies have increasingly shown that the Blood-Cerebrospinal ...