Contextual Neural Dynamics during Time Perception in the Primate Ventral Premotor Cortex

Neural Dynamics of Time Perception in the Ventral Premotor Cortex Academic Background Time perception is one of the central questions in neuroscience, particularly how the brain encodes time information as cognitive demands change. Time can be categorized as “long” or “short,” or it can be precisely represented as continuous intervals. The ventral ...

Active Vision in Freely Moving Marmosets Using Head-Mounted Eye Tracking

Study of Visual Behavior in Freely Moving Primates: Development and Application of an Innovative Eye-Tracking System Academic Background The visual system is one of the most extensively studied areas within the primate nervous system, particularly concerning the mechanisms of visual pathways in the cerebral cortex. However, current research on how ...

Evidence for Domain-General Arousal from Semantic and Neuroimaging Meta-Analyses Reconciles Opposing Views on Arousal

Neuroscientific Research Report on “Domain-General Arousal” Academic Background Arousal is a core concept in neuroscience, referring to fluctuations in brain and body states that underpin motivated behavior. Despite the widespread use of the term “arousal,” its definition has remained ambiguous, with differing interpretations in various textbooks. ...

Fixational Eye Movements as Active Sensation for High Visual Acuity

Fixational Eye Movements as Active Sensation for High Visual Acuity Academic Background Human visual perception is a complex process, especially when we attempt to maintain stable gaze. Even then, the eyes still produce small involuntary movements known as fixational eye movements (FEM). These FEM typically include drifts and microsaccades. Previou...

Intracranial Substrates of Meditation-Induced Neuromodulation in the Amygdala and Hippocampus

Study on the Neuroregulatory Effects of Meditation: A Case Study of Loving-Kindness Meditation Academic Background Meditation, as a mental training technique, has long been believed to regulate emotions and enhance mental health. Specifically, Loving-Kindness Meditation (LKM), which focuses on cultivating positive emotions towards oneself and other...

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Multi-Ancestry Genome-Wide Association Study Reveals New Loci for Prostate-Specific Antigen Levels and Improves Prediction Across Ancestral Groups Research Background and Problem Statement Prostate-specific antigen (PSA) is a protein secreted by the prostate gland, commonly used for prostate cancer screening. However, PSA levels are influenced not ...

Mechanistic Insights into Inactivating Mutations in the Proton-Coupled Folate Transporter (SLC46A1), and Compensatory Mutations that Restore Function

Research Background and Problem Statement Hereditary Folate Malabsorption (HFM) is a rare autosomal recessive disorder characterized by impaired intestinal absorption of folates and hindered transport across the choroid plexus into cerebrospinal fluid. This disease is caused by inactivating mutations in the gene encoding the Proton-Coupled Folate T...

A Statistical Framework for Multi-Trait Rare Variant Analysis in Large-Scale Whole-Genome Sequencing Studies

A New Framework for Multi-Trait Rare Variant Analysis: Multistaar Research Background and Problem Statement With the advancement of next-generation sequencing technologies and the decreasing cost of whole-genome sequencing (WGS), researchers can delve deeper into the impact of rare variants on complex human traits. However, single-trait analysis me...

The Association of Physical Activity Fragmentation with All-Cause Mortality in Hispanics: A Prospective Cohort Study

Research Background and Question In modern society, the patterns of physical activity (PA) and their impact on health have been a critical area of public health and medical research. Traditional studies have primarily focused on the total volume and intensity of physical activity. However, in recent years, an increasing number of studies have begun...

The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa

Research Background Current Status and Challenges in Hidradenitis Suppurativa Research Hidradenitis Suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. It affects approximately 1% of the global population, disproportionately impacting women and marginalized groups. HS’s pathogenesis is complex, involving genetic, im...