Neural Mechanisms and Relational Learning: Rapid Knowledge Reassembly in Neural Networks Background Humans and animals possess a remarkable ability to learn relationships between items in experience (such as stimuli, objects, and events), enabling structured generalization and rapid information assimilation. A fundamental type of such relational le...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

Study on the Hypothalamus-Habenula Circuit Regulating Risk Preference Academic Background In complex and uncertain environments, animals need to assess risks to make survival-favorable decisions. When faced with safe and risky options, animals usually exhibit a strong preference for one option, which remains consistent over time. However, how this ...

Large field-of-view, single-cell-resolution two- and three-photon microscope for deep and wide imaging Research Background and Problem Statement Multiphoton microscopy (MPM) is a powerful tool for deep tissue imaging, especially in the study of brain function in vivo. However, while traditional two-photon microscopy (2PM) can achieve a larger imagi...

Image Synthesis Under Limited Data: A Survey Research Background and Problem Statement In recent years, deep generative models have achieved unprecedented progress in intelligent creation tasks, especially in areas such as image and video generation, and audio synthesis. However, the success of these models relies heavily on large amounts of traini...

Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...

Academic Background In the mammalian neocortex, somatostatin (SST)-expressing neurons are a major class of inhibitory interneurons that exhibit diversity in electrophysiology and morphology, and are involved in various cognitive functions such as learning, memory, and sensory processing. However, despite extensive research on the diversity of SST n...

Neuropathic Changes in Pancreatic Cancer Academic Background Pancreatic cancer is one of the most lethal cancers today, characterized by late diagnosis and high aggressiveness. Despite some progress in diagnosis and treatment in recent years, the five-year survival rate for pancreatic cancer remains extremely low, at only around 12%. The pathogenes...

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...

Academic Background Chronic autoimmune diseases are typically triggered by a combination of genetic predisposition and environmental factors, with complex and incompletely understood mechanisms. In many cases, these diseases require lifelong immunosuppressive treatments, imposing a heavy burden on patients. Recent research has found that gut microb...